131028-54-1

Basic information

• Product Name: [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL
• Synonyms: [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL;{4-[2-(Dimethylamino)ethoxy]phenyl}methanol 97%
• CAS NO: 131028-54-1
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195.26
• Mol File: 131028-54-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 317°Cat760mmHg
• Flash Point: 145.5°C
• Appearance: /
• Density: 1.061g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.532
• PKA: 14.50±0.10(Predicted)
• CAS DataBase Reference: [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL(131028-54-1)
• EPA Substance Registry System: [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL(131028-54-1)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 131028-54-1(Hazardous Substances Data)

Usage

General Description

[4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL is a chemical compound that belongs to the class of phenyl methanols. It is a derivative of 4-hydroxyphenethylamine and contains an additional dimethylamino ethoxy group. [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL has potential applications in the fields of pharmaceuticals, agrochemicals, and materials science due to its unique chemical structure and properties. It may also have uses in the development of new drugs or as a building block for the synthesis of other complex organic molecules. Furthermore, it is important to handle this compound with care and follow proper safety protocols, as it may have hazardous properties and should be used in accordance with relevant regulations and guidelines.

InChI:InChI=1/C11H17NO2/c1-12(2)7-8-14-11-5-3-10(9-13)4-6-11/h3-6,13H,7-9H2,1-2H3

Upstream product

• 73119-82-1 methyl 4-<2-(dimethylamino)ethoxy>benzoate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1208752-16-2 methyl 4-{[2-(dimethylamino)-2-oxoethyl]oxy}benzoate 
• 15182-92-0 4-(2-dimethylaminoethoxy)benzaldehyde 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 52191-15-8 4-(2-bromoethyloxy)benzaldehyde 
• 124-40-3 dimethyl amine 
• 38459-72-2 (4-(2-bromoethoxy)phenyl)methan-1-ol 

Downstream Products

• 1240518-20-0 5-chloro-N-[(5-chloro-2-thienyl)sulfonyl]-N-[1-[(4-{[2-(dimethylamino)ethyl]oxy}phenyl)methyl]-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide 
• 1240516-91-9 5-chloro-N-[1-{[4-{[2-(dimethylamino)ethyl]oxy}-3-(methyloxy)phenyl]methyl}-4-(methyloxy)-1H-indazol-3-yl]-2-thiophenesulfonamide 
• 122898-67-3 itopride 
• 138-56-7 Trimethobenzamide 
• 122892-31-3 N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide hydrochloride 
• 1381978-64-8 3-(1-(4-(2-(dimethylamino)ethoxy)benzyl)naphthalen-2-yloxy)propan-1-ol 
• 1381977-24-7 2-(1-(4-(2-(dimethylamino)ethoxy)benzyl)naphthalen-2-yloxy)ethanol 
• 1381986-56-6 1-[4-{2-(dimethylamino)ethoxy}benzyl]naphthalen-2-ol hydrochloride 
• 1335047-79-4 1-[4-[2-(dimethylamino)ethoxy]benzyl]naphthalen-2-ol 
• 1261297-32-8 cyclopropyl{4-[4-(2-(dimethylamino)ethoxy)]benzyloxy}phenylmethanone 
• 859392-99-7 {2-[4-(3,7-dimethoxy-benzo[4,5]thieno[3,2-b]indol-10-ylmethyl)-phenoxy]-ethyl}-dimethyl-amine 
• 859392-97-5 {2-[4-(7-methoxy-benzo[4,5]thieno[3,2-b]indol-10-ylmethyl)-phenoxy]-ethyl}-dimethyl-amine 
• 131028-55-2 [2-(4-Chloromethyl-phenoxy)-ethyl]-dimethyl-amine 

Relevant articles and documents

NTCP INHIBITORS

Provided are cyclosporin A analogues that are NTCP inhibitors and useful for treating HBV and/or HDV infection (s), hepatoprotection and amelioration of hypercholesterolemia, diabetes and inhibiting cancer.

Itopride preparation method

The invention discloses an itopride preparation method, the method comprises the steps of 1, 2-(dimethylamino) chloroethane hydrochloride and hydroxybenzaldehyde synthesizing into 4-(2- dimethylamino ethoxy) benzaldehyde, then synthesizing into 4-(2- dimethylamino ethoxy) benzyl alcohol in alcohol solvent by revivification; 2, in alcohol solvent 3, 4-dimethoxy benzaldehyde and hydroxylamine hydrochloride creating reaction, then in nonpolar solvent synthesizing into 3, 4- dimethoxybenzonitrile by dehydration using the dehydrant; 3, the 4-(2-dimethylamino ethoxy) benzyl alcohol and the 3, 4- dimethoxybenzonitrile synthesizing into itopride in one step; 4, obtaining hydrochloric acid itopride by dissolving itopride in hydrogen chloride alcohol solution and salifying. The adopted raw material in the method is wide in sourcing scope, simple in preparation processing, and is suitable for large scale industrialization production; the preparation process involves no danger process, the production equipment is simple, the synthesized circuit is shorter than the existed circuits, the preparation time is short and the use effect is good.

Design, synthesis and bioevaluation of novel candidate selective estrogen receptor modulators

In an systematic attempt to develop novel Selective Estrogen Receptor Modulators (SERMs), chiral 1-((4-(2-(dialkylamino)ethoxy)phenyl)(2- hydroxynaphthalen-1-yl)methyl)piperidin-4-ols were designed based on an accepted pharmacophore model. Simpler prototypes, viz. racemic 1-((2-hydroxynaphthalen- 1-yl)arylmethyl)piperidin-4-ols, were first synthesized to develop kinetic resolution to pure enantiomers. Simultaneously, a series of racemic 1-((4-(2-(dialkylamino)ethoxy)phenyl)(2-hydroxynaphthalen-1-yl)methyl) piperidin-4-ols were evaluated against estrogen-responsive human MCF-7 breast cancer cells, but the compounds were found to be moderately active. The lack of potency could be due to the molecular bulk resulting in inadequate fit at the receptor. Subsequently, the molecular motif was modified to achiral 1-(4-(2-(dialkylamino)ethoxy)benzyl)naphthalen-2-ols by removing the piperidinol moiety. Bioevaluation of this new series of compounds displayed significantly enhanced cytotoxicity against MCF-7 cells. A representative compound for this series showed estrogen receptor alpha binding activity and the action is that of an antagonist.