1310708-96-3Relevant academic research and scientific papers
Cobalt-catalyzed intramolecular decarbonylative coupling of acylindoles and diarylketones through the cleavage of C-C bonds
Lu, Hong,Wei, Hao,Xu, Wen-Hua,Yu, Tian-Yang
, p. 12336 - 12340 (2020)
We report here cobalt-N-heterocyclic carbene catalytic systems for the intramolecular decarbonylative coupling through the chelation-assisted C-C bond cleavage of acylindoles and diarylketones. The reaction tolerates a wide range of functional groups such as alkyl, aryl, and heteroaryl groups, giving the decarbonylative products in moderate to excellent yields. This transformation involves the cleavage of two C-C bonds and formation of a new C-C bond without the use of noble metals, thus reinforcing the potential application of decarbonylation as an effective tool for C-C bond formation. This journal is
Rhodium-catalyzed regioselective direct C-H arylation of indoles with aryl boronic acids
Wang, Liang,Qu, Xing,Li, Zhan,Peng, Wang-Ming
supporting information, p. 3754 - 3757 (2015/06/08)
A highly efficient Rh(III)-catalyzed direct C-H arylation of indoles with aryl boronic acids under mild conditions has been developed. The methodology features wide substrate scope and excellent functional group compatibility (34 examples, up to 99% yield). The arylated products can also be conveniently transformed into biologically active polycyclic indole derivatives.
Rhodium-catalyzed decarbonylative direct C2-arylation of indoles with aryl carboxylic acids
Zhang, Lingjuan,Xue, Xiao,Xu, Conghui,Pan, Yixiao,Zhang, Guang,Xu, Lijin,Li, Huanrong,Shi, Zhangjie
, p. 3069 - 3074 (2015/02/02)
A RhI-catalyzed direct C2-arylation of indoles with diversely substituted aryl carboxylic acids has been developed using 2-pyrimidyl group as an easily installable and readily removable N-directing group. The reaction proceeded smoothly without the need for any external oxidants under relatively mild conditions to produce the C2-arylated indoles in high yields with excellent regioselectivity. A range of functional groups in both coupling partners were tolerated regardless of their electronic properties and positions. With the assistance of the 2-pyrimidyl group, these C2-functionalized products could further undergo C7-arylation to give the C7-aryl indole products. Mechanistic evidence supports that the reaction involves a decarbonylation step, and the carboxylic acids could be activated in situ by treatment with (tBuCO)2O to generate the active anhydrides.
Ruthenium-catalyzed direct C-H bond arylations of heteroarenes
Ackermann, Lutz,Lygin, Alexander V.
, p. 3332 - 3335 (2011/09/12)
Ruthenium-catalyzed C-H bond arylations of indoles, thiophenes, and pyrroles were accomplished in a highly chemo- and site-selective manner through the use of removable directing groups.
