Bioorganic and Medicinal Chemistry Letters p. 4730 - 4734 (2017)
Update date:2022-08-05
Topics:
Barberis, Claude
Moorcroft, Neil
Arendt, Chris
Levit, Mikhail
Moreno-Mazza, Sandra
Batchelor, Joseph
Mechin, Ingrid
Majid, Tahir
Novel N-substituted azaindoles have been discovered as PIM1 inhibitors. X-ray structures have played a significant role in orienting the chemistry effort in the initial phase of hit confirmation. Disclosure of an unconventional binding mode for 1 and 2, as demonstrated by X-ray crystallography, is presented and was an important factor in selecting and advancing a lead series.
View MoreNaturalin Bio-Resource Co., Ltd
website:http://www.naturalin.com
Contact:+86-0731-84430651
Address:B1-402, Lu-Valley Enterprise Square.No.27 Wenxuan Road. Lu-Valley Hi-Tech District.
Changzhou Ruiping Chemical Co., Ltd
website:http://www.wishchem.com
Contact:+86-519-82324280
Address:No.288-1 Huacheng Road, Jintan
Qingdao Kylin Trading Co., Ltd.
Contact:0086-532-68979884/58972912/68972263/65/88171519
Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
Shanghai He Yang International Trading Co., Ltd.
Contact:+86-21-52043598
Address:Room 816, Blag.5, No.58 Huachi Road
Synchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong,Yuandong Road Fengxian District, Shanghai ,China
Doi:10.1021/co200072z
(2011)Doi:10.1021/jo00001a024
(1991)Doi:10.1002/chem.201100872
(2011)Doi:10.1055/s-1990-27045
(1990)Doi:10.1016/S0040-4039(00)98057-2
(1990)Doi:10.1002/hlca.201000356
(2011)