131267-80-6Relevant articles and documents
Epristeride intermediate, preparation method of Epristeride intermediate, and preparation method of Epristeride
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Paragraph 0059; 0096; 0100; 0106-0108, (2018/03/24)
The invention relates to the field of medicine, in particular to an Epristeride intermediate, a preparation method of the Epristeride intermediate, and a preparation method of Epristeride. The preparation method of the Epristeride intermediate comprises the following steps that a compound 3 takes a sulfonation reaction with an alkaline reagent to produce a compound 4; the reaction conversion is single; the column chromatography isolation is avoided; the alkaline reagent used in the reaction process can be easily obtained; the reaction conditions are mild. The unit operation is reduced; the production period is shortened; the production efficiency is improved; the production efficiency is high; the economic benefits are improved.
PROCESS FOR THE PREPARATION OF 17?-SUBSTITUTED-3-OXO-4-AZA-5ALPHA-ANDROSTANE DERIVATIVES
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Page/Page column 7, (2008/06/13)
Process for the preparation of 17?-substituted-3-oxo-4-aza-5α-androstane derivatives, which are useful intermediates for the synthesis of 3-oxo-4-aza-5α-androst-1-ene derivatives including finasteride, is provided.
4-Oxa and 4-thia steroids
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, (2008/06/13)
The compounds of the present invention are those of structural formula (I) STR1 wherein X is oxygen or sulfur. Pharmaceutical compositions and methods of use of the compounds in the treatment of hyperandrogenic conditions are disclosed. In addition, the combination of the compounds with other active agents such as finasteride, minoxidil and retinoic acid or a derivative thereof is disclosed.