1530-73-0

Usage

Uses

Used in Pharmaceutical Industry:
N,N'-BIS(P-TOLUOYL)HYDRAZINE is used as a starting material for the synthesis of pharmaceutical compounds, leveraging its high reactivity and ability to form stable complexes with various metals. This property makes it a valuable component in the development of new drugs and therapeutic agents.
Used in Chemical Reactions:
In the field of organic chemistry, N,N'-BIS(P-TOLUOYL)HYDRAZINE is used as a reagent in various chemical reactions, contributing to the synthesis of a wide range of organic compounds. Its high reactivity and metal-complexing ability make it a versatile component in chemical processes.
Used in Coordination Chemistry:
N,N'-BIS(P-TOLUOYL)HYDRAZINE is utilized in coordination chemistry for its ability to form stable complexes with metals. This characteristic is valuable in the study and development of new coordination compounds and their applications in various fields, including catalysis and materials science.
Used in Chelation Processes:
In chemical and biological systems, N,N'-BIS(P-TOLUOYL)HYDRAZINE is employed in chelation processes to bind and stabilize metal ions. This application is particularly useful in the development of chelating agents for environmental remediation, medical treatments, and other applications where metal ion management is crucial.

Upstream product

• 13222-85-0 p-methylbenzoic anhydride 
• 3619-22-5 p-toluic hydrazide 
• 874-60-2 4-methyl-benzoyl chloride 
• 99-94-5 p-Toluic acid 
• 194033-79-9 2,2,3-tribromopropanoic acid 
• 78-74-0 1,1,2-tribromoethane 
• 74-86-2 acetylene 
• 75-80-9 2,2,2-tribromoethanol 
• 27949-36-6 1-dibromo-2-chloroethane 
• 141-52-6 sodium ethanolate 
• 7664-41-7 ammonia 
• 613-94-5 benzoic acid hydrazide 
• 50-00-0 formaldehyd 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 1874-47-1 2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole 
• 2491-91-0 2,5-di-p-tolyl-1,3,4-oxadiazole 
• 58370-38-0 diethyl 4-(5-(4-(diethoxyphosphino)methylphenyl)-1,3,4-oxadiazol-2-yl)-benzyl-phosphonate 
• 3005-30-9 3,5-di-p-tolyl-4H-{1,2,4}triazole 
• 1312991-48-2 6-methyl-3,4-diphenylisoquinolin-1(2H)-one 
• 16112-33-7 2,5-bis(4-methylphenyl)-1,3,4-thiadiazole 
• 10465-75-5 1,2-Bis(4-methylbenzoyl)diazene 

Relevant academic research and scientific papers

Oxidation of Hydrazides Using Sodium Perborate: Formation of N,N′-Diacylhydrazines

Substituted aromatic hydrazides react very smoothly with sodium perborate in glacial acetic acid at room temperature to give N,N′-diacylhydrazines in excellent yields and purity.

Discovery and Computational Rationalization of Diminishing Alternation in [n]Dendralenes

The [n]dendralenes are a family of acyclic hydrocarbons which, by virtue of their ability to rapidly generate structural complexity, have attracted significant recent synthetic attention. [3]Dendralene through [8]dendralene have been previously prepared but no higher member of the family has been reported to date. Here, we describe the first chemical syntheses of the "higher" dendralenes, [9]dendralene through [12]dendralene. We also report a detailed investigation into the spectroscopic properties and chemical reactivity of the complete family of fundamental hydrocarbons, [3]dendralene to [12]dendralene. These studies reveal the first case of diminishing alternation in behavior in a series of related structures. We also report a comprehensive series of computational studies, which trace this dampening oscillatory effect in both spectroscopic measurements and chemical reactivity to conformational preferences.

Polymer light-emitting diodes based on a bipolar transporting luminescent polymer

A soluble electroluminescent polymer containing hole-deficient triphenylamine and electron-deficient oxadiazole units in the main chains has been designed and studied. The design is based on the consideration that the triphenylamine group possesses good hole-transporting property and the oxadiazole unit is known to be of electron-transporting character. Because of the good bipolar transporting performance, the brightness and electroluminescent efficiency are significantly improved and the turn-on voltage is reduced compared with a similar polymer without the electron-deficient oxadiazole units in the main chains. For a device with configuration ITO/PEDOT/polymer/CsF/Al, a maximum brightness of 3600 cd m-2 and a maximum luminescent efficiency of 0.65 cd A-1 (quantum efficiency of 0.3%) were obtained in the polymer with oxadiazole units, about 15 times brighter and 15 times more efficient than the corresponding polymer without oxadiazole units.

Hypervalent iodine oxidation of acid hydrazides: A new synthesis of N,N'-diacylhydrazines

Hypervalent iodine oxidation of p-substituted benzohydrazides (1a-h), phenylacetohydrazide (1i) and heterocyclic acid hydrazides (1j-l) using one equivalent of iodobenzene diacetate in dry dichloromethane or acetonitrile leads to dimerization thereby providing a new and facile method for the synthesis of N,N-diacylhydrazines 2.

Synthesis and characterization of a novel charge transfer compound with large three-photon absorption cross section

A new intramolecular charge transfer compound containing diethylamino group as electronic donor and oxadiazole group as electronic acceptor has been synthesized using Wittig-Horner reaction. This long conjugated molecule has large three-photon absorption cross section excited at 1.06 μm lasing.

Catalytic Enantioselective Synthesis of 1,4-Keto-Alkenylboronate Esters and 1,4-Dicarbonyls

A catalytic enantioselective method for the synthesis of 1,4-keto-alkenylboronate esters by a rhodium-catalyzed conjugate addition pathway is disclosed. A variety of novel, bench-stable alkenyl gem-diboronate esters are synthesized. These easily accessible reagents react smoothly with a collection of cyclic α,β-unsaturated ketones, generating a new C?C bond and stereocenter. Products are isolated in up to 99 % yield with greater than 20:1 E/Z and greater than 99:1 e.r. Mechanistic studies show the site-selectivity of transmetalation and reactivity is ligand dependent. The utility of the approach is highlighted by gram-scale synthesis of enantioenriched cyclic 1,4-diketones, and stereoselective transformations of the products by hydrogenation, allylation, and isomerization.

Synthesis and in vitro urease inhibitory activity of benzohydrazide derivatives, in silico and kinetic studies

Benzohydrazide derivatives 1–43 were synthesized via “one-pot” reaction and structural characterization of these synthetic derivatives was carried out by different spectroscopic techniques such as 1H NMR and EI-MS. The synthetic molecules were evaluated for their in vitro urease inhibitory activity. All synthetic derivatives showed good inhibitory activities in the range of (IC50 = 0.87 ± 0.31–19.0 ± 0.25 μM) as compared to the standard thiourea (IC50 = 21.25 ± 0.15 μM), except seven compounds 17, 18, 23, 24, 29, 30, and 41 which were found to be inactive. The most active compound of the series was compound 36 (IC50 = 0.87 ± 0.31 μM) having two chloro groups at meta positions of ring A and methoxy group at para position of ring B. The structure–activity relationship (SAR) of the active compounds was established on the basis of different substituents and their positions in the molecules. Kinetic studies of the active compounds revealed that compounds can inhibit enzyme via competitive and noncompetitive modes. In silico study was also performed to understand the binding interactions of the molecules (ligand) with the active site of enzyme.

Rapid and Atom Economic Synthesis of Isoquinolines and Isoquinolinones by C–H/N–N Activation Using a Homogeneous Recyclable Ruthenium Catalyst in PEG Media

Herein, we report an atom-efficient, rapid, green, and sustainable approach to synthesize isoquinolines and isoquinolinones using a homogeneous recyclable ruthenium catalyst in PEG Media assisted by microwave energy. Dibenzoylhydrazine was used for C–H/N–N activation reactions for the first time in combination with ketazine as oxidizing directing groups for annulation reactions with internal alkynes. The developed protocol is environmentally benign due to significantly shortened times with an easy extraction method, higher atom economy, external oxidant and silver or antimony salt free conditions, applicability to a gram scale synthesis, use of biodegradable solvent and wide substrate scope with higher product yields. Moreover, it is worth noting that the established methodology allowed reuse of the catalytic system for up to five successive runs with minimal loss in activity.

Method for producing 1,1-dibromo-1-fluoroethane

The present invention addresses the problem of providing a production method which enables 1,1-dibromo-1-fluoroethane to be produced in a simple and sustained manner. The present invention provides a method for producing 1,1-dibromo-1-fluoroethane, said method comprising step A of reacting 1,1-dibromoethylene with hydrogen fluoride to produce 1,1-dibromo-1-fluoroethane.

METHOD FOR PRODUCING 1,1-DIBROMO-1-FLUOROETHANE

An object of the present invention is to provide a production method that makes it possible to produce 1,1-dibromo-1-fluoroethane easily and sustainably. The present invention provides a method for producing 1,1-dibromo-1-fluoroethane, the method comprising step A of reacting 1,1-dibromoethylene with hydrogen fluoride to obtain 1,1-dibromo-1-fluoroethane.