1313026-26-4Relevant articles and documents
The first generation of β-galactosidase-responsive prodrugs designed for the selective treatment of solid tumors in prodrug monotherapy
Legigan, Thibaut,Clarhaut, Jonathan,Tranoy-Opalinski, Isabelle,Monvoisin, Arnaud,Renoux, Brigitte,Thomas, Mika?l,Le-Pape, Alain,Lerondel, Stéphanie,Papot, Sébastien
, p. 11606 - 11610 (2012)
Massive attack: Galactoside prodrugs have been designed that can be selectively activated by lysosomal β-galactosidase located inside cancer cells expressing a specific tumor-associated receptor. This efficient enzymatic process triggers a potent cytotoxic effect, releasing the potent antimitotic agent MMAE and allowing the destruction of both receptor-positive and surrounding receptor-negative tumor cells. Copyright
CONJUGATES AND PRODRUGS FOR TREATING OF CANCER AND INFLAMMATORY DISEASES
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Paragraph 0174; 0175, (2017/08/01)
The present invention relates to the field of cancer and inflammatory diseases. More particularly, it aims to provide, for these purposes, novel conjugated forms of active ingredients belonging to the dolastatin family and having the formula as follows: It is also directed towards prodrug forms of these conjugates.