131303-37-2

Upstream product

• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 870-63-3 prenyl bromide 
• 35458-19-6 1-[2,4,6-trihydroxy-3,5-di(3-methyl-2-buten-1-yl)phenyl]ethanone 
• 107-30-2 chloromethyl methyl ether 

Downstream Products

• 162663-65-2 5,7-Bis-methoxymethoxy-6,8-bis-(3-methyl-but-2-enyl)-2-phenyl-chroman-4-one 
• 129314-38-1 (+/-)-5,7-dihydroxy-6,8-diprenylflavanone 
• 212265-21-9 6,8-bis(3-methyl-2-butenyl)-5,7,2',4',6'-pentamethoxymethoxyflavanone 
• 624734-51-6 5,7-di(methoxymethoxy)-6,8-di-C-prenyl-4'-O-prenylflavanone 
• 162663-64-1 (E)-1-[2-Hydroxy-4,6-bis-methoxymethoxy-3,5-bis-(3-methyl-but-2-enyl)-phenyl]-3-phenyl-propenone 

Relevant academic research and scientific papers

First total synthesis of (±)-kenusanone b

The first total synthesis of a natural prenylflavanone, (±)-kenusanone B (1) has been achieved by condensation of acetophenone 4 and benzaldehyde 6 followed by cyclization and deprotection. Chloromethyl methyl ether was used as a facile protecting reagent of free hydroxy groups for the synthesis of polyhydroxylated flavanones.

Synthesis of 5,7-dihydroxy-6,8-di-C-prenyl-4′-O-prenyl-flavanone

The prenylated flavanone (9) has been synthesized from phloroacetophenone (1). All the new products have been characterized by the spectral data and microanalysis.

Synthesis of 5,7,4'-trihydroxy-6-C-prenylflavone

5,7,4'-Trihydroxy-6-C-prenylflavone 6 isolated from the fruits of Maclura pomifera has been synthesized by the following route. Phloroacetophenone 1 on treatment with methoxymethyl chloride afford 2- hydroxy-4,6-di(methoxymethoxy) acetophenone 2 which on

STUDIES ON THE PRENYLFLAVONOIDS PART XV. SYNTHESIS OF (+/-)-SPINOFLAVANONE B

Spinoflavanone B was prepared for the first time by the condensation of 2-hydroxy-4,6-dimethoxymethoxy-3,5-diprenylacetophenone with benzaldehyde followed by cyclization and demethoxymethylation.