13133-05-6

Usage

InChI:InChI=1/C10H10O6/c1-15-5-3-6(9(11)12)8(10(13)14)7(4-5)16-2/h3-4H,1-2H3,(H,11,12)(H,13,14)

Upstream product

• 58545-97-4 4,6-dimethoxy-phthalide 
• 65565-44-8 2,3,5,7-tetramethoxy-[1,4]naphthoquinone 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 76697-63-7 4,6-Dimethoxyphthalid-3-carbonsaeure 
• 63585-71-7 4,6-dimethoxy-3-trichloromethyl-1-benzo[c]furanone 
• 1132-21-4 3,5-dimethoxybenzoic acid 
• 62827-47-8 3-hydroxy-7,9-dimethoxy-1-methyl-6H-benzo[c]chromen-6-one 
• 3209-07-2 3,5-dihydroxyphthalic acid 
• 62827-49-0 2-bromo-4,6-dimethoxybenzoic acid 
• 23452-05-3 alternariol-9-methyl ether 
• 604-46-6 2,3,5,7-tetrahydroxy-1,4-naphthoquinone 
• 13872-98-5 3,7,9-trimethoxy-1-methyl-6H-dibenzo[b,d]pyran-6-one 
• 24953-73-9 Dimethyl 3,5-dimethoxyphthalate 

Downstream Products

• 4670-17-1 3,5-dimethoxyphthalic anhydride 

Relevant academic research and scientific papers

Synthesis and biological activity of new phthalimides as potential anti-inflammatory agents

The overproduction of nitric oxide (NO) plays an important role in a variety of pathophysiological processes, including inflammation. Therefore, the suppression of NO production is a promising target in the design of anti-inflammatory agents. In the prese

Design, Synthesis, Molecular Docking, and Biological Evaluation of New Emodin Anthraquinone Derivatives as Potential Antitumor Substances

The emodin anthraquinone derivatives are generally used in traditional Chinese medicine due to their various pharmacological activities. In the present study, a series of emodin anthraquinone derivatives have been designed and synthesized, among which 1,3-dihydroxy-6,8-dimethoxyanthracene-9,10-dione is a natural compound that has been synthesized for the very first time, and 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione is a compound that has never been reported earlier. Interestingly, while total seven of these compounds showed neuraminidase inhibitory activity in influenza virus with inhibition rate more than 50 %, specific four compounds exhibited significant inhibition of tumor cell proliferation. The further results demonstrate that 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione showed the best anticancer activity among all the synthesized compounds by inducing highest apoptosis rate to HCT116 cancer cells and arresting their G0/G1 cell cycle phase, through elevation of intracellular level of reactive oxygen species (ROS). Moreover, the binding of 1,3-dimethoxy-5,8-dimethylanthracene-9,10-dione with BSA protein has thoroughly been investigated. Altogether, this study suggests the neuraminidase inhibitory activity and antitumor potential of the new emodin anthraquinone derivatives.

Method for synthesizing 3,5-dimethoxy-phthalic anhydride as medicine intermediate

The invention provides a method for synthesizing 3,5-dimethoxy-phthalic anhydride as a medicine intermediate. The method includes the steps of firstly adding a certain amount of methyl 3,5-dimethoxybenzoate and chloral hydrate into a four-necked bottle, a