1313516-28-7

Basic information

• Product Name: (S)-methyl 3-(N-(6-acetylnaphthalen-2-yl)-2-nitrophenylsulfonamido)-2-(tritylamino)propanoate
• CAS NO: 1313516-28-7
• Molecular Weight: 713.811
• Mol File: 1313516-28-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-methyl 3-(N-(6-acetylnaphthalen-2-yl)-2-nitrophenylsulfonamido)-2-(tritylamino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 3-(N-(6-acetylnaphthalen-2-yl)-2-nitrophenylsulfonamido)-2-(tritylamino)propanoate(1313516-28-7)
• EPA Substance Registry System: (S)-methyl 3-(N-(6-acetylnaphthalen-2-yl)-2-nitrophenylsulfonamido)-2-(tritylamino)propanoate(1313516-28-7)

Safety Data

• Hazardous Substances Data: 1313516-28-7(Hazardous Substances Data)

Upstream product

• 15231-91-1 6-bromo-naphthalen-2-ol 
• 1313516-29-8 N-tert-butoxycarbonyl-6-acetyl-2-naphthylamine 
• 13515-76-9 methyl N-trityl-L-serinate 
• 1590-25-6 1-(6-bromonaphthalen-2-yl)ethanone 
• 10441-41-5 1-(6-hydroxy-2-naphthyl)ethan-1-one 
• 7470-88-4 1-(6-aminonaphthalen-2-yl)ethanone 
• 151600-02-1 6-bromo-2-naphthalenyl trifluoromethanesulfonate 
• 580-13-2 2-bromonaphthalene 

Relevant articles and documents

Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid

Fluorescent unnatural amino acids (UAAs), when genetically incorporated into proteins, can provide unique advantages for imaging biological processes in vivo. Synthesis of optically pure l-enantiomer of fluorescent UAAs is crucial for their effective application in live cells. An efficient six-step synthesis of l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid (l-Anap), a genetically encodable and polarity-sensitive fluorescent UAA, has been developed. The synthesis takes advantage of a high-yield and enantiospecific Fukuyama-Mitsunobu reaction as the key transformation.