7470-88-4

Usage

InChI:InChI=1/C12H11NO/c1-8(14)9-2-3-11-7-12(13)5-4-10(11)6-9/h2-7H,13H2,1H3

Upstream product

• 75-36-5 acetyl chloride 
• 91-59-8 naphthalen-2-ylamine 
• 580-13-2 2-bromonaphthalene 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 1334019-93-0 Peroxy Naphthalene 1 
• 151600-02-1 6-bromo-2-naphthalenyl trifluoromethanesulfonate 
• 1590-25-6 1-(6-bromonaphthalen-2-yl)ethanone 
• 1313516-29-8 N-tert-butoxycarbonyl-6-acetyl-2-naphthylamine 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 10441-41-5 1-(6-hydroxy-2-naphthyl)ethan-1-one 
• 581-97-5 2-acetylaminonaphthalene 

Downstream Products

• 1032729-48-8 C₄₀H₄₅N₃O₁₁ 
• 1185251-08-4 3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid 
• 1313516-26-5 (S)-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid 
• 1313516-28-7 (S)-methyl 3-(N-(6-acetylnaphthalen-2-yl)-2-nitrophenylsulfonamido)-2-(tritylamino)propanoate 
• 1334019-93-0 Peroxy Naphthalene 1 
• 68520-00-3 1-(6-(dimethylamino)naphthalen-2-yl)ethan-1-one 
• 1554027-08-5 1-(5-bromo-6-{(E)-[4-(dimethylamino)phenyl]diazenyl}naphthalen-2-yl)ethanone 
• 1554027-11-0 1-(6-{(E)-[4-(dimethylamino)phenyl]diazenyl}naphthalen-2-yl)ethanone 
• 1554027-13-2 [1-(6-{(E)-[4-(dimethylamino)phenyl]diazenyl}naphthalen-2-yl)ethylidene]propanedinitrile 

Relevant academic research and scientific papers

Loss of thioredoxin reductase function in a mouse stroke model disclosed by a two-photon fluorescent probe

Thioredoxin reductase (TrxR) enzymes are critical in regulating redox homeostasis in cells. We report the first two-photon fluorescent probe of mammalian TrxR (TP-TRFS). TP-TRFS retains high specificity in recognizing TrxR. More importantly, the two-photon absorbing character of TP-TRFS enables it to be used in vivo. With the aid of TP-TRFS, a remarkable decline of the TrxR function was observed in the brain of a mouse model of stroke for the first time, providing a mechanistic link of TrxR dysfunction with stroke. This journal is

A sensitive two-photon ratiometric fluorescent probe for γ-glutamyltranspeptidase activity detection and imaging in living cells and cancer tissues

We develop a novel two-photon ratiometric fluorescent probe based on the conjugation of the specific recognition moiety of the γ-glutamyl group to 6-acetyl-2-aminonaphthalene, which enables highly sensitive, selective monitoring of γ-glutamyltransferase activities in human serum and imaging in living cells and cancer tissues down to a depth of 120 μm.

PRODAN fluorescent dye with red fluorescence and large Stokes shift, and synthesis method and application thereof

The invention discloses a PRODAN fluorescent dye with red fluorescence and large Stokes shift, and a synthesis method and an application thereof. The dye has a structure defined in the specification, wherein R1 is one of C1-20 alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, hydroxyl, cyano or alkoxy; R2, R3, R4 and R5 are respectively one or two or more of H, C1-20 alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, (CH2)nOH, (CH2)nCOOM, (CH2)nSO3M, heteroaryl or substituted heteroaryl; n is an integer of 0-12; M is one or two or more of H, K, Na, Li, NH4, NH3R6, NH2(R6)2, NH(R6)3 or N(R6)4; R6 is one or two or more of H and C1-20 alkyl. The obtained dye has relatively high light stability, has the fluorescence emission wavelength at about 582 nm, also has relatively large Stokes shift and relatively high fluorescence quantum yield, and can be applied in luminescent materials, biological fluorescent probes, biological fluorescent imaging and other fields.

Light-Harvesting Systems Based on Organic Nanocrystals To Mimic Chlorosomes

We report the first highly efficient artificial light-harvesting systems based on nanocrystals of difluoroboron chromophores to mimic the chlorosomes, one of the most efficient light-harvesting systems found in green photosynthetic bacteria. Uniform nanocrystals with controlled donor/acceptor ratios were prepared by simple coassembly of the donors and acceptors in water. The light-harvesting system funneled the excitation energy collected by a thousand donor chromophores to a single acceptor. The well-defined spatial organization of individual chromophores in the nanocrystals enabled an energy transfer efficiency of 95%, even at a donor/acceptor ratio as high as 1000:1, and a significant fluorescence of the acceptor was observed up to donor/acceptor ratios of 200 000:1.

Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells

The synthesis of fluorescent unnatural amino-acid Anap was optimized and the Anap was incorporated into four sites in an acid-pocket or a transmembrane region of human acid-sensing ion channel-1a (hASIC1a). Combinational Anap fluorescence spectra and patc

Assessing the guest-accessible volume in MOFs using two-photon fluorescence microscopy

The assessment of guest-accessible volume in MOFs can be reliably done by using two-photon confocal fluorescence microscopy (TPM) with a tool-box of dyes with a wide range of sizes. It would be applicable to any porous materials, whose single-crystal structures are not available, or non-crystalline materials.

Elongation of the molecular probe DDNP with phenylethynylidene or phenyldiazenylidene spacers

In this work, we report the synthesis, X-ray structures, and optical properties of two DDNP analogs containing an unsaturated spacer inserted between the donor N,N-dimethylamino group and the naphthalene ring. The new compounds have longer distances betwe

Enantiospecific synthesis of genetically encodable fluorescent unnatural amino acid l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid

Fluorescent unnatural amino acids (UAAs), when genetically incorporated into proteins, can provide unique advantages for imaging biological processes in vivo. Synthesis of optically pure l-enantiomer of fluorescent UAAs is crucial for their effective application in live cells. An efficient six-step synthesis of l-3-(6-acetylnaphthalen-2-ylamino)-2-aminopropanoic acid (l-Anap), a genetically encodable and polarity-sensitive fluorescent UAA, has been developed. The synthesis takes advantage of a high-yield and enantiospecific Fukuyama-Mitsunobu reaction as the key transformation.

A two-photon fluorescent probe for ratiometric imaging of hydrogen peroxide in live tissue

We report a two-photon fluorescent probe (PN1) that can be excited by 750 nm femto-second pulses, shows high photostability and negligible toxicity, and can visualize H2O2 distribution in live cells and tissue by two-photon microscopy. The Royal Society of Chemistry 2011.

Two-photon probe for real-time monitoring of intracellular calcium ions, method for preparing the probe and method for real-time monitoring of intracellular calcium ions using the probe

A two-photon probe for real-time monitoring of intracellular calcium ions is provided. The two-photon probe is very suitable for real-time imaging of intracellular calcium ions, shows 20-50-fold TPEF enhancement in response to Ca2+, has a disso