131403-83-3Relevant academic research and scientific papers
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target
Mc Gee, Margaret M.,Gemma, Sandra,Butini, Stefania,Ramunno, Anna,Zisterer, Daniela M.,Fattorusso, Caterina,Catalanotti, Bruno,Kukreja, Gagan,Fiorini, Isabella,Pisano, Claudio,Cucco, Carla,Novellino, Ettore,Nacci, Vito,Williams, D. Clive,Campiani, Giuseppe
, p. 4367 - 4377 (2007/10/03)
We have recently developed five novel pyrrolo-1,5-benzoxazepines as proapoptotic agents. Their JNK-dependent induction of apoptosis in tumor cells suggested their potential as novel anticancer agents. The core structure of the apoptotic agent 6 was invest
Apoptosis-inducing compounds
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, (2008/06/13)
The present invention relates to pyrrolobenzoxazepines, pyrrolobenzthiazepines and related compounds having the ability to induce apoptosis, to pharmaceutical compositions comprising these compounds and to their use as anti-tumour agents.
Research on compounds with psychotropic activity IX - synthesis of 6-p-methoxyphenylpyrrolo[2,1-d][1,5]benzothiazepines and evaluation of their affinities for BDZ and GABA receptor subtypes
Nacci,Fiorini,Garofalo,Cagnotto
, p. 545 - 557 (2007/10/02)
6-p-Methoxyphenylpyrrolo[2,1-d][1,5]benzothiazepin-7(6H)-one (IV), cis-7-acetoxy-6,7-dihydro-6-p-methoxyphenylpyrrolo[2,1- d][1,5]benzothiazepine (V) and some significant 7-acyloxy-6-p-methoxyphenylpyrrolo[2,1- d][1,5]benzothiazepines (VI a-g) were synthe
