13143-02-7

Basic information

• Product Name: (4-acetylphenyl)urea
• Synonyms: (4-acetylphenyl)urea;Nsc27464;1-(4-acetylphenyl)urea
• CAS NO: 13143-02-7
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.19
• Mol File: 13143-02-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 329.7°Cat760mmHg
• Flash Point: 153.2°C
• Appearance: /
• Density: 1.261
• Vapor Pressure: 0.000174mmHg at 25°C
• Refractive Index: 1.617
• PKA: 14.29±0.50(Predicted)
• CAS DataBase Reference: (4-acetylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: (4-acetylphenyl)urea(13143-02-7)
• EPA Substance Registry System: (4-acetylphenyl)urea(13143-02-7)

Safety Data

• Hazardous Substances Data: 13143-02-7(Hazardous Substances Data)

Usage

General Description

(4-Acetylphenyl)urea, also known as N-(4-Acetylphenyl)urea, is an organic compound that is made up of a urea molecule with an acetylphenyl group attached to it. It is a white crystalline solid that is insoluble in water but soluble in organic solvents. This chemical is used in various industrial applications as a reagent in the synthesis of other organic compounds. It is also utilized in the manufacture of pharmaceuticals and as a component in chemical research and development. The (4-Acetylphenyl)urea compound has a range of uses and is an important building block in the production of various organic materials.

InChI:InChI=1/C9H10N2O2/c1-6(12)7-2-4-8(5-3-7)11-9(10)13/h2-5H,1H3,(H3,10,11,13)

Upstream product

• 64-10-8 phenyl carbamate 
• 75-36-5 acetyl chloride 
• 75106-15-9 4-acetylphenyl cyanamide 
• 917-61-3 sodium isocyanate 
• 99-92-3 p-aminobenzophenone 
• 893187-73-0 C₁₆H₁₆N₂O₂ 
• 99-90-1 para-bromoacetophenone 
• 590-28-3 potassium cyanate 

Downstream Products

• 116433-14-8 C₃₄H₃₂N₆O₈S 

Relevant articles and documents

A green and facile approach for the synthesis of N-monosubstituted ureas in water: Pd catalyzed reaction of arylcyanamides (an unexpected behavior of electron withdrawing groups)

The Fe3O4 magnetic nano-particles were prepared, coated with tetraethyl orthosilicate (TEOS), functionalized with 3-chloropropyltrimethoxysilane (CPTMS), further functionalized with 2,2′-(piperazine-1,4-diylbis(methylene) dianiline (PDMD) and the corresponding Pd complex synthesized as a novel nano-magnetic heterogeneous catalyst (Fe3O4@SiO2@CPTMS@PDMD@Pd) to be used for the synthesis of various N-monosubstituted ureas in water. Also, in another attempt to see the effect of HCOOH, the hydration reaction of arylcyanamide was carried out in the presence of HCOOH (water + 98% HCOOH) which had two effects: it decreased the amount of the Pd catalyst from 40 to 30 mg, and the reaction condition was changed from the reflux condition to room temperature. Interestingly, the arylcyanamides with electron withdrawing groups influence the course of the reaction and need more reaction times for completion which is an unexpected behavior, probably due to the high electron density around the central carbon atom of the nitrile group.

Hybrid Pd/Fe3O4 nanowires: Fabrication, characterization, optical properties and application as magnetically reusable catalyst for the synthesis of N-monosubstituted ureas under ligand-free conditions

This paper reports the synthesis and use of Pd/Fe3O4 nanowires, as magnetically separable catalysts for ligand-free amidation coupling reactions of aryl halides with benzylurea under microwave irradiation. Then, the in situ hydrogenolysis of the products was performed to afford the N-monosubstituted ureas from good to excellent yields. This method has the advantages of high yields, simple methodology and easy work up. The catalyst can be recovered by using a magnet and reused several times without significant loss of its catalytic activity. The catalyst was characterized using the powder XRD, SEM, EDS and UV-vis spectroscopy. Experimental absorbance spectra was compared with results from the Gans theory.