1315257-13-6

Basic information

• Product Name: 6-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one
• Synonyms: 6-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one
• CAS NO: 1315257-13-6
• Molecular Weight: 329.374
• Mol File: 1315257-13-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one(1315257-13-6)
• EPA Substance Registry System: 6-fluoro-2-methyl-3,4-diphenylisoquinolin-1(2H)-one(1315257-13-6)

Safety Data

• Hazardous Substances Data: 1315257-13-6(Hazardous Substances Data)

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 701-49-5 4-fluoro-N-methylbenzamide 
• 501-65-5 diphenyl acetylene 
• 3400-22-4 4-methoxy-N-methylbenzamide 

Relevant articles and documents

Pd/C-catalyzed synthesis of N-aryl and N-alkyl isoquinolones via C[sbnd]H/N[sbnd]H activation

Pd/C-catalyzed direct synthesis of N-aryl and N-alkyl isoquinolones was developed via the annulation reactions of benzamides and alkynes in high yields (up to 99%) through the cleavage of C[sbnd]H/N[sbnd]H bonds. The reaction was ligand-free and air was used as oxidant. High regioselectivities were found when unsymmetrical alkynes or meta-benzamides were used as substrates. The heterocyclic carboxamide substrates, such as furan and thiophene derivatives, also afforded the corresponding products in high yields.