13159-21-2

Upstream product

• 24463-87-4 (5-chloropent-1-ynyl)benzene 
• 105-53-3 diethyl malonate 
• 109-70-6 1.3-chlorobromopropane 
• 536-74-3 phenylacetylene 
• 57718-13-5 (5-bromo-pent-1-ynyl)-benzene 

Downstream Products

• 13159-22-3 diethyl (Z)-2-(5-phenylpent-4-enyl)malonate 
• 13159-20-1 7c-Phenyl-hept-6-ensaeure 
• 1350704-06-1 2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione 
• 1350703-96-6 (E)-2,2-dimethyl-5-(4-phenylbut-3-en-1-yl)-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione 
• 1350703-99-9 (E)-5-(4-(2,4-dichlorophenyl)but-3-en-1-yl)-2,2-dimethyl-5-(5-phenylpent-4-yn-1-yl)-1,3-dioxane-4,6-dione 

Relevant academic research and scientific papers

SYNTHESIS OF CAPSAICIN DERIVATIVES

The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.

Radical cyclization cascades of unsaturated Meldrum's acid derivatives

Unsaturated, differentially substituted Meldrum's acid derivatives undergo cascade cyclizations upon ester reduction with SmI2-H2O. The cascade cyclizations proceed in good yield and with high diastereocontrol and convert simple, ach