131647-65-9Relevant academic research and scientific papers
Nucleophile-Induced Rearrangement of 2 H-Azirine-2-carbonyl Azides to 2-(1 H-Tetrazol-1-yl)acetic Acid Derivatives
Efimenko, Nikita I.,Khlebnikov, Alexander F.,Novikov, Mikhail S.,Spiridonova, Dar'ya V.,Tomashenko, Olesya A.
supporting information, p. 6362 - 6366 (2021/09/02)
2H-Azirine-2-carbonyl azides undergo a rearrangement into derivatives of 2-(1H-tetrazol-1-yl)acetic acid when interacting with O- and S-nucleophiles at room temperature. The reaction is catalyzed by tertiary amines or hydrazoic acid. The reaction with primary alcohols and phenols gives alkyl/aryl 2-(1H-tetrazol-1-yl)acetates. Thiophenols react with 2H-azirine-2-carbonyl azides to afford S-aryl 2-(1H-tetrazol-1-yl)ethanethioates. The mechanism of the nucleophile-induced rearrangement of 2H-azirine-2-carbonyl azides is discussed on the basis of DFT calculations as well as kinetic and 15N labeling experiments.
Novel Bis(2-(5-((5-phenyl-1H-tetrazol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)phenoxy)Alkanes: Synthesis and Characterization
Saeed, Aamer,Qasim, Muhammad,Hussain, Majid
, p. 1114 - 1118 (2015/08/06)
In this study, 10 different substituted aromatic bis-benzaldehydes were synthesized by treating hydroxy benzaldehydes with various dihaloalkanes. Bis aldehydes 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j were treated with 2-(5-phenyl-1H-tetrazole-1-yl)acetohyd
TETRAZOLE DERIVATIVES AND ALDOSE REDUCTASE INHIBITION THEREWITH
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, (2008/06/13)
The present invention relates to an aldose reductase inhibitor having the following formula: R1 is a hydrogen atom or --A--COOR5 (A is an alkylene group having 1 to 4 carbon atoms and R5 is a hydrogen atom or a lower alkyl group), and R2, R3 and R4 are the same as or different from each other and selected from the group consisting of a hydrogen atom, a hydroxy group, a halogen atom, a carboxyl group, an alkyl group, an amide group, an amino group, an alkoxy group, an aryl group, an aryloxy group, an alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, a nitro group, --NHCOCOOR6 (R6 is a hydrogen atom or a lower alkyl group), a mono or dialkylaminosulfonyl group, and a residual group having the following formula: (A and R5 are the same as in the above). The compounds defined in the above are excellent in aldose reductase inhibitory activity and low in toxicity. Therefore, those compounds are useful as a preventive agent and/or a remedy for diabetic complications such as neuropathy, retinopathy, nephropathy, cataracts and keratopathy
