13165-33-8

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 10 carbon (C), 15 hydrogen (H), 1 bromine (Br), 1 nitrogen (N), and 2 oxygen (O) atoms.

Explanation

The compound is derived from benzene, a six-carbon ring with alternating single and double bonds. It has a bromine atom (Br) attached to one of the carbons in the ring and two hydroxyethylamine groups (N,N-bis(2-hydroxyethyl)amino) attached to another carbon in the ring.

Explanation

The compound contains a bromine atom (bromo), two hydroxyethylamine groups (N,N-bis(2-hydroxyethyl)amino), and a phenyl group (the benzene ring with the substituents).

Explanation

The appearance of the compound (e.g., color, state of matter) is not mentioned in the given information.

Explanation

The solubility of the compound in various solvents (e.g., water, organic solvents) is not mentioned in the given information.

Explanation

The stability of the compound under different conditions (e.g., temperature, pH) is not mentioned in the given information.

Explanation

The compound serves as a building block for the creation of other complex organic molecules, particularly in the pharmaceutical industry.

Explanation

The compound has been studied for its potential therapeutic uses in treating specific diseases, as well as its utility in constructing more complex organic molecules for various applications.

Explanation

The compound's unique structure and functional groups make it a valuable tool for researchers working in organic chemistry and the development of new drugs and pharmaceuticals.

Structure

Substituted benzene with a bromo group and two hydroxyethylamine groups

Functional groups

Bromo, hydroxyethylamine, and phenyl

Synthesis

Used in the synthesis of various pharmaceuticals and organic compounds

Potential applications

Treatment of certain diseases and as a building block for complex organic molecules

Importance

Significant for scientists and researchers in the field of organic chemistry and drug development

Upstream product

• 120-07-0 2,2'-(phenylimino)bis[ethanol] 
• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 106-40-1 4-bromo-aniline 
• 107-07-3 2-chloro-ethanol 
• 540-51-2 2-bromoethanol 
• 148717-08-2 N,N-bis[2-[(1-tert-butyl-1,1-diemthylsilyl)oxy]ethyl]-N-phenylamine 

Downstream Products

• 147621-98-5 (4-Bromo-phenyl)-bis-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-amine 
• 871660-02-5 4-bromo-N,N-bis[2-(p-toluenesulfonyl)ethyl]aniline 
• 871660-03-6 4-bromo-N,N-bis(2-iodoethyl)aniline 
• 871660-04-7 13-(4-bromophenyl)-1,4,7,10-tetrathia-13-azacyclopentadecane 
• 1428438-50-9 C₁₈H₁₆BrNO₄ 
• 1422986-76-2 2,2'-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)azanediyl)bis(ethan-1-ol) 
• 1422986-77-3 N,N-bis(2-chloroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1422986-49-9 C₁₇H₂₇BClNO₅S 
• 1422986-44-4 2-((2-bromoethyl)(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino)ethyl methanesulfonate 
• 1434078-71-3 C₁₆H₂₄BBr₂NO₂ 
• 1422986-54-6 2,2′-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylazanediyl)bis(ethane-2,1-diyl) dimethanesulfonate 
• 1422986-78-4 N-(2-bromoethyl)-N-(2-chloroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 
• 1422986-56-8 C₁₂H₁₈BrNO₆S₂ 
• 1422986-68-2 4-(bis(2-chloroethyl)amino)phenylboronic acid 

Relevant academic research and scientific papers

{[K.18-Crown-6]Br3}n: a unique tribromide-type and columnar nanotube-like structure for the oxidative coupling of thiols and bromination of some aromatic compounds

Reaction of 18-crown-6 with KBr and then with bromine (Br2) afforded a unique tribromide salt with a nanotube-like structure ({[K.18-crown-6]Br3}n). Oxidative coupling of thiols and bromination of some aromatic compounds is the first report on the chemistry of this reagent.

Fluorescent periodic mesoporous organosilica nanoparticles dual-functionalized: Via click chemistry for two-photon photodynamic therapy in cells

The synthesis of ethenylene-based periodic mesoporous organosilica nanoparticles for two-photon imaging and photodynamic therapy of breast cancer cells is described. A dedicated two-photon absorbing fluorophore possessing four triethoxysilyl groups and ha

A two-photon fluorescence probe for cell membrane imaging under temporal-focusing multiphoton excitation microscopy (TFMPEM)

A small-sized chromophore, BTTA-2OH, manifesting favorable solubility, large two-photon excitation efficiency, and good fluorescence photostability was synthesized to label the membrane of living cells for visualizing the dynamic movement of membrane-rela

Twofold photoswitching of NIR fluorescence and EPR based on the PMI-N-HABI for optical nanoimaging of electrospun polymer nanowires

In this article, we report the design and synthesis of a fluorescent molecular switch based on perylenemonoimide-hexaarylbiimidazole dyad (PMI-N-HABI), which exhibits not only photoswitchable near-infrared (NIR) fluorescence but also photoswitchable elect

Reactive oxygen species (ROS) inducible DNA cross-linking agents and their effect on cancer cells and normal lymphocytes

Reducing host toxicity is one of the main challenges of cancer chemotherapy. Many tumor cells contain high levels of ROS that make them distinctively different from normal cells. We report a series of ROS-activated aromatic nitrogen mustards that selectively kill chronic lymphocytic leukemia (CLL) over normal lymphocytes. These agents showed powerful DNA cross-linking abilities when coupled with H2O2, one of the most common ROS in cancer cells, whereas little DNA cross-linking was detected without H2O2. Consistent with chemistry observation, in vitro cytotoxicity assay demonstrated that these agents induced 40-80% apoptosis in primary leukemic lymphocytes isolated from CLL patients but less than 25% cell death to normal lymphocytes from healthy donors. The IC50 for the most potent compound (2) was ～5 μM in CLL cells, while the IC 50 was not achieved in normal lymphocytes. Collectively, these data provide utility and selectivity of these agents that will inspire further and effective applications.

ANTI-CANCER AGENTS

Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.

A Green protocol for the bromination and iodination of the aromatic compounds using H5IO6/NaBr and H5IO 6/NaI in the water

Bromination and iodination of the aromatic compounds have efficiently been carried out at room temperature and 70 °C, respectively, in short reaction times using orthoperiodic acid/sodium bromide (1:2) and orthoperiodic acid/sodium iodide (1:2) in water to prepare the corresponding halo compounds with excellent yields.

Synthesis, crystal structure and biological activity of novel diester cyclophanes

A series of novel diester cyclophanes was synthesized by esterification of 1,2-benzenedicarbonyl chloride with eight different diols under high dilution conditions. The structures of the compounds were verified by elemental analysis, 1H nuclear magnetic resonance (NMR), IR spectroscopy and high resolution mass spectrometry (HRMS). The crystal structures of two compounds were characterized by single crystal X-ray diffractometry (XRD). All the new cyclophanes were evaluated for biological activities and the results showed that some of these compounds have low antibacterial or antifungal activities.

Electrophilic bromination of alkenes, alkynes, and aromatic amines with iodic acid/potassium bromide under mild conditions

Bromination of alkenes, alkynes, and aromatic amines has efficiently been carried out at room temperature in short reaction times using HIO 3/KBr in CH2Cl2/H2O (1:1) to prepare corresponding brominated compounds in excellent yields.

Elctrophilic bromination of alkenes, alkynes, and aromatic amines with potassium bromide/orthoperiodic acid under mild conditions

Bromination of alkenes, alkynes, and aromatic amines has efficiently been carried out at room temperature in short reaction times using potassium bromide/orthoperiodic acid in dichloromethane-water (1:1) to prepare the corresponding bromo compounds with excellent yields.