131941-25-8

Basic information

• Product Name: 2-(4-METHOXYPHENYL)-5-NITROPYRIDINE
• Synonyms: 2-(4-METHOXYPHENYL)-5-NITROPYRIDINE
• CAS NO: 131941-25-8
• Molecular Formula: C₁₂H₁₀N₂O₃
• Molecular Weight: 230.22
• Mol File: 131941-25-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 132-135
• Boiling Point: 379.7 °C at 760 mmHg
• Flash Point: 183.4 °C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 1.25E-05mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(4-METHOXYPHENYL)-5-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-METHOXYPHENYL)-5-NITROPYRIDINE(131941-25-8)
• EPA Substance Registry System: 2-(4-METHOXYPHENYL)-5-NITROPYRIDINE(131941-25-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 131941-25-8(Hazardous Substances Data)

Usage

General Description

2-(4-Methoxyphenyl)-5-nitropyridine is a chemical compound with the molecular formula C12H9N3O3. It consists of a pyridine ring with a nitro group at the 5-position and a methoxyphenyl group at the 2-position. This chemical is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a versatile building block in organic chemistry and has potential applications in the development of new drugs and materials. 2-(4-Methoxyphenyl)-5-nitropyridine is commonly used as a reagent in research and industrial laboratories for its unique chemical properties and reactivity.

InChI:InChI=1/C12H10N2O3/c1-17-11-5-2-9(3-6-11)12-7-4-10(8-13-12)14(15)16/h2-8H,1H3

Upstream product

• 4487-59-6 2-bromo-5-nitropyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 4548-45-2 2-chloro-5-nitropyridine 
• 33397-21-6 tris(4-methoxyphenyl)bismuth 
• 14150-94-8 3,5-dinitro-1-methyl-2-pyridone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 52057-98-4 6-(4-methoxyphenyl)pyridine-3-ylamine 

Relevant articles and documents

Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity

Receptor tyrosine kinase PDGFRα is often constitutively activated in various tumours and is regarded as a drug target. Here, we present a collection of 2,6,9-trisubstituted purines with nanomolar potency against PDGFRα and strong and selective cytotoxicity in the human eosinophilic leukaemia cell line EOL-1 that expresses the FIP1L1-PDGFRA oncogene. In treated EOL-1 cells, the example compound 14q inhibited the autophosphorylation of PDGFRα and the phosphorylation of STAT3 and ERK1/2. Interestingly, we observed pronounced and even increased effects of 14q on PDGFRα and some of its downstream signalling pathways after drug washout. In accordance with suppressed PDGFRα signalling, treated cells were arrested in the G1 phase of the cell cycle and eventually underwent apoptosis. Our results show that substituted purines can be used as specific modulators of eosinophilic leukaemia.

Cross-coupling study of iodo/chloropyridines and 2-chloroquinoline with atom-economic triarylbismuth reagents under Pd-catalysis

This study describes the palladium-catalyzed couplings of iodopyridines, chloropyridines, and chloroquinoline with atom-economic BiAr3 reagents in sub-stoichiometric loadings. Mono-arylations of iodo and chloropyridines produced arylpyridines i

NAPHTHALENE DERIVATIVE

The present invention provides compounds which can regulate VCP activity. The present invention provides the compound of formula (I) (R is as defined in the description) or oxides, esters, prodrugs, pharmaceutically acceptable salts or solvates thereof. The compounds can regulate VCP activity, and thus are useful for treating VCP-mediated diseases such as neurodegenerative diseases.