131968-75-7

Upstream product

• 38870-89-2 Methoxyacetyl chloride 
• 783-08-4 [4-(benzylideneamino)phenyl]methanol 
• 100-52-7 benzaldehyde 
• 104-94-9 4-methoxy-aniline 
• 94612-26-7 trans-1-(4'-methoxyphenyl)-3-chloro-3-phenylthio-4-phenylazetidin-2-one 
• 625-45-6 2-methoxyacetic acid 
• 1613-90-7 4-methoxy-N-[(E)-phenylmethylidene]aniline 

Relevant academic research and scientific papers

Triphosgene, an efficient acid activator for the Staudinger reaction

An efficient one-step synthesis of β-lactams by the reaction of imines with acids in the presence of triphosgene and triethylamine has been described.

Preparation of 2-azetidinones by cyclocondensation of carboxylic acids and imines via diphosphorustetraiodide

One-pot mild synthesis of 2-azetidinones was carried out by the reaction of imines and carboxylic acids in dry dichloromethane at room temperature using diphosphorus tetraiodide. It was also applied for synthesis of 3-spiro-2-azetidinones. The synthesized

Microwave-induced cycloaddition of imines with acid chlorides in absence of a tertiary amine: Unprecedented synthesis of β-lactams in dimethylformamide

Synthesis β-lactams in N,N-dimethylformamide proceeds through cycloaddition of acid chlorides with imines in a domestic microwave oven in the absence of a tertiary base. This is an unprecedented observation.

A mild and selective reduction of β-lactams: Rh-catalyzed hydrosilylation towards important pharmacological building blocks

Four-membered N-heterocyclic compounds exhibit a broad range of pharmacological activities. Herein, we report a useful rhodium-catalyzed protocol for the activation of phenylsilane to reduce tertiary β-lactams. Reaction with the tertiary amides was select

Facile stereoselective synthesis of cis- and trans-3-alkoxyazetidin-2-ones

A highly stereoselective synthesis of cis- and trans-3-alkoxy-3-phenyl/benzylthioazetidin-2-ones is described. The reaction of α-chlorosulfide-β-lactams with various alcohols catalyzed by a Lewis acid such as ZnCl2 in the presence of molecular

Synthesis of azetidin-2-one via in situ generated acid chlorides using hexachloroacetone-triethylphosphite

A one step synthesis of azitidine-2-ones 3a-i has been described by the reaction of imines 2 with acids 1 in the presence of hexachloroacetone, triethylphosphite and triethylamine.

Triphosgene: A versatile reagent for the synthesis of azetidin-2-ones

An efficient use of triphosgene, as an acid activator, for the synthesis of substituted azetidin-2-ones via ketene-imine cycloaddition reaction using various acids and imines have been described.

Synthesis of azetidin-2-ones from imines and acids using trichloroacetonitrile-triphenylphosphine reagent

A one step synthesis of azetidin-2-ones (3a-j) has been described by the reaction of imines (1) with acids (2) in presence of trichloroacetonitrile, triphenylphosphine and triethylamine.

An improved method for the stereoselective synthesis of β-lactams from carboxylic acids and imines

Carboxylic acids activated with Mukaiyama's reagent (2-chloro-N-methylpyridinium iodide) reacted with imines to produce β-lactams in good yields and with high stereoselectivity. The utilization of three equivalents of tripropylamine as the base was necess

Highly stereoselective synthesis of α-hydroxy β-amino acids through β-lactams: Application to the synthesis of the taxol and bestatin side chains and related systems

Formation of α-hydroxy β-lactams, followed by chemical elaboration at C4 and further β-lactam cleavage afforded functionalised α-hydroxy β-amino acids or their derivatives in a highly stereoselective manner.