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5-Hydroxyindole-3-acetic acid, also known as 5-HIAA, is an organic compound that serves as an intermediate in the synthesis of magnolol derivatives with antidepressant properties. It is also a biochemical marker for neuroendocrine tumors.
Used in Pharmaceutical Industry:
5-Hydroxyindole-3-acetic acid is used as an intermediate in the preparation of magnolol derivatives for their antidepressive potential. It plays a crucial role in the development of novel antidepressant drugs.
Used in Medical Diagnostics:
5-Hydroxyindole-3-acetic acid is used as a biochemical marker for neuroendocrine tumors, aiding in the diagnosis and monitoring of these conditions.
Used in Pharmaceutical Manufacturing:
5-Hydroxyindole-3-acetic acid is used as an impurity in the production of chlorpheniramine, an antihistaminic agent. Its presence is essential for the synthesis process of this medication.

1321-73-9

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1321-73-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1321-73-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,2 and 1 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1321-73:
(6*1)+(5*3)+(4*2)+(3*1)+(2*7)+(1*3)=49
49 % 10 = 9
So 1321-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)

1321-73-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (5-Hydroxy-1H-indol-3-yl)acetic acid

1.2 Other means of identification

Product number -
Other names (5-HYDROXY-1H-INDOL-3-YL)-ACETIC ACID

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1321-73-9 SDS

1321-73-9Related news

Simultaneous determination of norepinephrine, serotonin, and 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine08/26/2019

A microbore column liquid chromatographic method for the simultaneous determination of norepinephrine (NE), serotonin (5-HT), and 5-hydroxyindole-3-acetic acid (5HIAA) in microdialysis samples from rat brain is described. The method is based on precolumn derivatization of NE, 5HT, and 5HIAA with...detailed

Urinary excretion patterns of 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) and 5-hydroxytryptophol in various animal species: Implications for studies on serotonin metabolism and turnover rate08/25/2019

The concentrations of the serotonin metabolites 5-hydroxyindole-3-acetic acid (5HIAA) and 5-hydroxytryptophol (5HTOL) were determined in spot urine samples of 12 mammalian and one fish species (cat, cow, dog, ferret, golden hamster, guinea pig, horse, monkey, mouse, rabbit, rainbow trout, rat, s...detailed

Urinary excretion of 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) and 5-hydroxytryptophol after oral loading with serotonin08/24/2019

The urinary excretion patterns of the serotonin (5-hydroxytryptamine; 5-HT) metabolites 5-hydroxyindole-3-acetic acid (5-HIAA) and 5-hydroxytryptophol (5-HTOL) were examined after ingestion of bananas, a food rich in 5-HT. The bananas contained on an average 25 μg 5-HT/g pulp. Both urinary 5-HI...detailed

Simple and rapid determination of 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) in urine by direct injection on a liquid chromatographic column08/23/2019

5-Hydroxyindole-3-acetic acid has been determined at normal and increased levels in urine. The urine samples were filtered or centrifuged and then injected into a liquid Chromatograph containing a reversed phase column with tributyl phosphate as stationary liquid phase and an aqueous buffer + me...detailed

Sensitive determination of deuterated and non-deuterated indole-3-acetic acid and 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) by combined capillary gas chromatography—negative-ion chemical ionization mass spectrometry08/22/2019

Sensitive methods for the determination of deuterated and non-deuterated indole-3-acetic acid and 5-hydroxyindole-3-acetic acid by combined capillary gas chromatography—negative-ion chemical ionization mass spectrometry were developed. Indole-3-acetic and 5-hydroxyindole-3-acetic acids were con...detailed

New microdialysis-electrochemical device for simultaneous determination of ascorbic acid and 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) in rat striatum08/20/2019

A new device combining microdialysis with electrochemical microsensor was developed. It can be applied to monitor the biomolecules in the brain for biological and pharmaceutical research. In this paper, the device was applied to simultaneously determine ascorbic acid (AA) and 5-hydroxyindole-3-a...detailed

ArticleThe Urinary Ratio of 5-Hydroxytryptophol to 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) in Surgical Patients with Chronic Alcohol Misuse08/19/2019

The urinary ratio of 5-hydroxytryptophol to 5-hydroxyindole-3-acetic acid was reported to be elevated for a period of up to 22 h following acute alcohol ingestion. Therefore, the ratio could detect continuous alcohol consumption, in what was considered to be a high-risk surgical group, on the ev...detailed

Photo-activated 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) induces apoptosis of prostate and bladder cancer cells08/18/2019

5-Hydroxyindole-3-acetic acid (5-HIAA), an indole derivative, is the main metabolite of serotonin in the human body. We determined whether or not ultraviolet B (UVB)-activated 5-HIAA (5-HIAAUVB) affects the viability of human prostate (LnCaP and PC-3) and bladder cancer cells (TCCSUP). While 5-H...detailed

Artificial enzyme-based catalytic sensor for the electrochemical detection of 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) tumor marker in urine08/17/2019

A novel approach towards the development of biomimetic electrochemical sensors is presented. It is based on magnetic-core/porous-shell molecularly imprinted composites as recognition phase. The selected substrate is 5-hydroxyindole-3-acetic acid (5-HIAA), an urinary metabolite used as carcinoid ...detailed

1321-73-9Relevant academic research and scientific papers

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