Urinary excretion of 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) and 5-hydroxytryptophol after oral loading with serotonin

Add time:08/24/2019    Source:sciencedirect.com

The urinary excretion patterns of the serotonin (5-hydroxytryptamine; 5-HT) metabolites 5-HYDROXYINDOLE-3-ACETIC ACID (cas 1321-73-9) (5-HIAA) and 5-hydroxytryptophol (5-HTOL) were examined after ingestion of bananas, a food rich in 5-HT. The bananas contained on an average 25 μg 5-HT/g pulp. Both urinary 5-HIAA and 5-HTOL increased markedly (15- to 30-fold) shortly after eating 3–4 bananas, with the highest concentrations found in urine specimens collected after 2–4 h, and did not return to normal until after 8–10 h. The excretion of 5-HIAA increased from a control mean value of 3.9 mg/24 h to 12.7 mg/24 h, when conventional diets were supplemented with 3–4 bananas. The corresponding results for 5-HTOL were 16.8 μg/24 h and 60.7 μg/24 h, respectively. Of the banana-derived 5-HT ingested, 60–80% was recovered in the urine as 5-HIAA and only 0.3–0.5% as 5-HTOL. However, since both the time-course and relative increase in 5-HTOL was similar to that of 5-HIAA, there was no effect on the urinary 5-HTOL to 5-HIAA ratio. By contrast, acute alcohol consumption produced a considerable elevation of this ratio.

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