132182-92-4

Basic information

• Product Name: 1,1,1,2,3,4,4,5,5,5-DECAFLUORO-3-METHOXY-2-(TRIFLUOROMETHYL)PENTANE
• Synonyms: 3-METHOXYPERFLUORO(2-METHYLPENTANE);1,1,1,2,3,4,4,5,5,5-DECAFLUORO-3-METHOXY-2-(TRIFLUOROMETHYL)PENTANE;1,1,1,2,3,4,4,5,5,5-Decafluoro-3-methoxy-2-methylpentane;3-METHOXYPERFLUORO(2-METHYLPENTANE), 98% MIN.;1,1,1,2,3,4,4,5,5,5,-Decafluoro-3-methoxy-2-(trifloromethyl)pentane;Pentane, 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-;1,1,1,2,2,3,4,5,5,5-Decafluoro-3-methoxy-4-(trifluoromethyl)pentane;Novec 7300
• CAS NO: 132182-92-4
• Molecular Formula: C₇H₃F₁₃O
• Molecular Weight: 350.08
• Mol File: 132182-92-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 100 °C
• Flash Point: 7.172°C
• Appearance: /
• Density: 1.67
• Vapor Pressure: 97.543mmHg at 25°C
• Refractive Index: 1.274
• Water Solubility: Insoluble in water
• CAS DataBase Reference: 1,1,1,2,3,4,4,5,5,5-DECAFLUORO-3-METHOXY-2-(TRIFLUOROMETHYL)PENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1,2,3,4,4,5,5,5-DECAFLUORO-3-METHOXY-2-(TRIFLUOROMETHYL)PENTANE(132182-92-4)
• EPA Substance Registry System: 1,1,1,2,3,4,4,5,5,5-DECAFLUORO-3-METHOXY-2-(TRIFLUOROMETHYL)PENTANE(132182-92-4)

Safety Data

• Hazardous Substances Data: 132182-92-4(Hazardous Substances Data)

Usage

Uses

1,1,1,2,2,3,4,5,5,5-Decafluoro-3-methoxy-4-(trifluoromethyl)pentane is used in preparation method of isolated Hydrofluoroether.

InChI:InChI=1/C7H3F13O/c1-21-4(11,3(9,10)7(18,19)20)2(8,5(12,13)14)6(15,16)17/h1H3

Synthetic route

Methyl methanesulfonate (66-27-3) + 1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
With potassium fluoride; 18-crown-6 ether In diethylene glycol dimethyl ether at 50℃; for 5h; Temperature;	90.83%

perfluoro-2-hexanone (755-27-1) + dimethyl sulfate (77-78-1) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
Stage #1: perfluoro-2-hexanone With potassium fluoride In diethylene glycol dimethyl ether at 20℃; for 4h; Stage #2: dimethyl sulfate In diethylene glycol dimethyl ether at 20℃; for 72h;	79.56%

2,3-bi(fluorosulfato)perfluoro-4-methylpentane (75677-98-4) + dimethyl sulfate (77-78-1) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 20℃; for 4h;	72%

perfluoro-2-methylpentan-3-one (756-13-8) + dimethyl sulfate (77-78-1) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
With potassium fluoride In diethylene glycol dimethyl ether at 45℃;

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) + methyl iodide (74-88-4) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
With potassium fluoride; 18-crown-6 ether In diethylene glycol dimethyl ether at 30℃; for 5h;

1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane (788-67-0) + dimethyl sulfate (77-78-1) → 1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4)

Conditions	Yield
With potassium fluoride; 18-crown-6 ether In N,N-dimethyl-formamide at 50℃; Solvent; Reagent/catalyst; Temperature;

1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)-pentane (132182-92-4) → 2-trifluoromethyl-3-chloromethoxyperfluoropentane + 2-trifluoromethyl-3-dichloromethoxyperfluoropentane

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); chlorine at 70℃;

Upstream product

• 66-27-3 Methyl methanesulfonate 
• 788-67-0 1,1,1,3,4,4,5,5,5-nonafluoro-2-trifluoromethyl-2,3-epoxypentane 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 755-27-1 perfluoro-2-hexanone 
• 756-13-8 perfluoro-2-methylpentan-3-one 
• 75677-98-4 2,3-bi(fluorosulfato)perfluoro-4-methylpentane 

Relevant articles and documents

Preparation method of isolated hydrofluoroether

The invention discloses a preparation method of isolated hydrofluoroether. The preparation method comprises the following steps: in the presence of inorganic fluoride and a co-catalyst, carrying out an alkylation reaction on perfluorinated epoxide and an alkylation reagent in an aprotic polar solvent to obtain the isolated hydrofluoroether. The main raw material perfluorinated epoxide can be prepared by epoxidation of perfluoro-olefin, the raw materials are simple and easy to obtain, the cost is lower than that of perfluorohexanone and perfluoroacyl fluoride compounds, the stability is good, the subsequent reaction is facilitated, and the quality can be ensured. The preparation method has the advantages that the reaction speed is high, the reaction time is short, the raw materials can be completely converted within 3-5 hours, the residual quantity of the raw material perfluorinated epoxy compound in the obtained crude product can be as low as 0.1% or below, and the reaction conversionrate is high. The content of the target product can reach 97% or above, the reaction selectivity is high, the byproducts are few, and the method is suitable for industrial application.

FLUOROALIPHATIC ESTERS OF FLUOROSULFONIC ACID. 2. REACTION BIS(FLUOROSULFATO)PERFLUOROALKANES WITH CESIUM FLUORIDE

2,3-Bis(fluorosulfato)perfluoroalkanes split under the action of CsF in the absence of solvents, giving a mixture of α-fluorosulfatoperfluoro ketones, perfluoroalkene sulfates, and perfluoro α-diketones.The occurence of these reactions in solutions results mainly in the formation of oxides of the corresponding fluoroolefins or products of their conversions.The reactions carried out are the first examples of nucleophilic substitution at a secondary carbon atom in a perfluorinated saturated chain.