132205-64-2

Upstream product

• 58485-68-0 1-chlorotetralin 
• 151-50-8 potassium cyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 119-64-2 tetralin 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 17336-59-3 1-tetralone tosylhydrazone 
• 333-20-0 potassium thioacyanate 
• 73599-59-4 Δ-3,4-naphthalene-1-carbonitrile 
• 50361-53-0 1-(trimethylsilyloxy)-1,2,3,4-tetrahydronaphthalene-1-carbonitrile 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 447-53-0 1,2-Dihydronaphthalene 
• 143-33-9 sodium cyanide 
• 90875-76-6 4-(2-chlorophenyl)butan-1-ol 
• 529-33-9 1,2,3,4-Tetrahydro-1-naphthol 

Downstream Products

• 1914-65-4 tetralin-1-carboxylic acid 
• 73599-59-4 Δ-3,4-naphthalene-1-carbonitrile 
• 86-53-3 1-Cyanonaphthalene 
• 125364-41-2 1-(4-Phenoxybutyl)-1-tetralincarbonsaeureamid 
• 157736-52-2 1-<<4-methylphenylsulfonyl>oxy>methyl-1,2,3,4-tetrahydro-1-naphthalinecarbonitrile 
• 98841-72-6 1,2,3,4-tetrahydronaphthalene-1-carboxamide 
• 84-22-0 tetrahydrozoline 

Relevant academic research and scientific papers

Redox catalysis in free-radical reactions: New, simple, convenient intramolecular homolytic aromatic substitutions

Three new general, simple and convenient procedures of intramolecular homolytic aromatic substitution leading to homocyclic and heterocyclic compounds have been developed by addition of aryl or nucleophilic alkyl radicals to alkenes conjugated with electron-withdrawing groups in the presence of metal salt redox systems.

First intramolecular alkylation of nitriles with primary and secondary alcohols catalyzed by iridium complexes

The first iridium-catalyzed intramolecular alkylation ofnitriles with primary and secondary alcohols through hydrogen transfer is described. This reaction allows access to precursors of biologically active arylmethylamines. The first iridium-catalyzed int

Asymmetric Deoxygenative Cyanation of Benzyl Alcohols Enabled by Synergistic Photoredox and Copper Catalysis?

Summary of main observation and conclusion. An enantioselective deoxygenative cyanation of benzyl alcohols was accomplished for the first time through the synergistic photoredox and copper catalysis. This reaction features the use of organic photosensitizer and low-cost 3d metal catalyst, simple and safe operations, and extremely mild conditions. A variety of chiral benzyl nitriles were produced in generally good yields and high level of enantiocontrols from readily available feedstocks (22 examples, up to 93% yield and 92% ee).

A metal-free direct C (sp3)-H cyanation reaction with cyanobenziodoxolones

A metal-free protocol of direct C(sp3)-H cyanation with cyanobenziodoxolones functioning as both cyanating reagents and oxidants was developed. Unactivated substrates, such as alkanes, ethers and tertiary amines, were thereby transformed to the corresponding nitriles in moderate to high yields. Mechanistic studies indicated that the cyanation proceeded with two potential pathways, which is highly dependent on the substrates: (1) a free radical case for alkanes and ethers and (2) an oxidative case for tertiary amines.

Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the "cN" Source

A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.

Enantioselective nickel-catalyzed hydrocyanation of vinylarenes using chiral phosphine-phosphite ligands and TMS-CN as a source of HCN

Anti-headache chemistry: In the presence of a tailored modular P,P ligand the nickel-catalyzed addition of HCN, generated in situ from TMS-CN, to styrene derivatives proceeds with an unprecedented level of stereocontrol (up to 97 % ee) to give 2-aryl-acetonitriles, for example, the depicted precursor of Ibuprofen. Copyright

Metal-free synthesis of polysubstituted pyrroles by (diacetoxyiodo)benzene- mediated cascade reaction of 3-alkynyl amines

Free metal jacket: A regioselective metal-free synthesis of polysubstituted pyrroles has been developed through a (diacetoxyiodo)benzene-mediated cascade reaction of alkynyl amines in moderate to good yield (see scheme).

Novel 2-imidazoles as potent and selective α1A adrenoceptor partial agonists

Novel 2-imidazoles have been identified as potent partial agonists of the α1A adrenergic receptor, with good selectivity over the α1B, α1D and α2A receptor sub-types. Sulfonamide 23 possessed attractive drug-like properties with respect to physicochemical and ADME properties and wide ligand selectivity.

INDANE COMPOUNDS AS CCR5 ANTAGONISTS

The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

Dephosphorylation of Cyano Diethyl Phosphates by Reduction with Lithium-Liquid Ammonia: An Efficient Method for Conversion of Carbonyl Compounds into Nitriles

Cyano diethyl phosphate derivatives of aromatic carbonyl compounds and α,β-unsaturated ketones were successively dephosphorylated by reduction with lithium in liquid ammonia followed by treatment with isoprene or alkyl halides to give β,γ-unsaturated nitriles or α-alkyl-β,γ-unsaturated nitriles in moderate to good yields.