132279-97-1Relevant academic research and scientific papers
Direct oxidative lactonization of alkenoic acids mediated solely by NaIO4: Beyond a simple oxidant
Kang, Yan-Biao,Chen, Xian-Min,Yao, Chuan-Zhi,Ning, Xiao-Shan
, p. 6193 - 6196 (2016)
Triflic acid-catalyzed direct oxidative lactonization of alkenoic acids mediated solely by NaIO4 without halogen salts is described. Sodium periodate works not only as an oxidant, but also as an active reagent and directly mediates the lactonization. A new cheap, green, and practical oxidative lactonization approach has been developed using NaIO4 as the sole reagent.
IODINE (III) MEDIATED ACETOXY-LACTONIZATION OF UNSATURATED NITRILES
Tiecco, Marcello,Testaferri, Lorenzo,Tingoli, Marco,Bartoli, Donatella
, p. 7139 - 7150 (2007/10/02)
4-Pentenenitriles reacted with PhI(OAc)2 in acetic acid, in the presence of 48percent HBF4, at 70 deg C, to afford the dihydro-5-acetoxymethyl-2(3H)-furanones in good yields.Similarly, 3-butenenitriles gave the dihydro-4-acetoxy-2(3H)-furanones, although in lower yields.Parallel experiments showed that, under the same conditions, 4-pentenoic and 3-pentenoic acids reacted much more easily and gave the same acetoxy-lactonization process at room temperature.
