32119-56-5Relevant academic research and scientific papers
A photoredox catalyzed radical-radical coupling reaction: Facile access to multi-substituted nitrogen heterocycles
Li, Weipeng,Duan, Yingqian,Zhang, Muliang,Cheng, Jian,Zhu, Chengjian
supporting information, p. 7596 - 7599 (2016/07/06)
Visible light induced photoredox catalysis is an efficient method for radical activation. Herein, we report the photoredox catalysis involving an intramolecular radical-radical coupling reaction that proceeds through a biradical intermediate. This protocol represents a new synthetic route to construct multi-substituted N-heterocycles. Four, five and six-membered N-heterocyclic structures with a quaternary carbon center are accessible under mild conditions.
N-Bromosuccinimide promoted and base switchable one pot synthesis of α-imido and α-amino ketones from styrenes
Shinde, Mahesh H.,Kshirsagar, Umesh A.
supporting information, p. 858 - 861 (2016/01/15)
An N-Bromosuccinimide (NBS) promoted one pot strategy for the synthesis of α-amino functionalized aryl ketones starting from commercially available styrenes has been developed. NBS participates in multiple tasks, such as bromonium ion formation, oxidation of bromohydrin and providing a nucleophilic nitrogen source. The reaction can easily be switched between α-imido and α-amino ketones by the choice of base. This one pot strategy was successfully applied for the synthesis of psychoactive drug candidates, amfepramone, mephedrone and 4-MEC.
Cyclisation indolique selon Bischler en presence d'acides de Lewis
Galons, Herve,Girardeau, Jean-Francois,Farnoux, Claude Combet,Miocque, Marcel
, p. 561 - 564 (2007/10/02)
In a comparative study of various catalysts (hydrochloric acid, Lewis acids) in the Bischler cyclization of α-aminoketones to indoles, aluminium chloride appears as the most active catalyst.Isomerization of β to α-indoles can be observed by raising the reaction temperature.The mechanism seems different from the one frequently suggested by most authors, since it does not affect intermediate aminoketones but indoles.
