1323344-95-1Relevant academic research and scientific papers
BODIPY-modified 2′-deoxyguanosine as a novel tool to detect DNA damages
Takamura-Enya, Takeji,Ishii, Ryoko
, p. 4206 - 4209 (2011)
BODIPY-modified 2′-deoxyguanosine was synthesized for use as a detection reagent for genotoxic compounds. BODIPY-FL is a well known fluorescence reagent whose fluorescent light emission diminishes near a guanine base by a photo-induced electron transfer process. We attached BODIPY-Fl to the 5′ position of the deoxyribose moiety of 2′-deoxyguanosine. Although this compound has low fluorescence activity, when depurination by the action of alkylating reagents and dG oxidation by singlet oxygen occurred, the emission of strong fluorescence was observed. BODIPY-dG was found, therefore, to be a very useful tool for selectively detecting DNA damaging activity particularly in natural environmental extracts.
Synthesis, Characterization, and Repair of a Flexible O6-2′-Deoxyguanosine-alkylene-O6-2′-deoxyguanosine Intrastrand Cross-Link
O'Flaherty, Derek K.,Wilds, Christopher J.
, p. 10522 - 10529 (2015)
Oligonucleotides tethered by an alkylene linkage between the O6-atoms of two consecutive 2′-deoxyguanosines, which lack a phosphodiester linkage between these residues, have been synthesized as a model system of intrastrand cross-linked (IaCL)
