132402-81-4Relevant academic research and scientific papers
Concise synthesis of stereodefined, thiazole - Containing cyclic hexa- and octapeptide relatives of the Lissoclinums, via cyclooligomerisation reactions
Bertram, Anna,Blake, Alexander J.,González-López De Turiso, Felix,Hannam, Jeffery S.,Jolliffe, Katrina A.,Pattenden, Gerald,Skae, Michael
, p. 6979 - 6990 (2003)
The synthesis of a range of thiazole containing cyclic peptides using cyclooligomerisation reactions of amino acid substituted thiazole monomers and by macrolactamisation procedures is reported. The synthetic approaches lead to high yields of novel 18- and 24-membered ring analogues of the naturally occurring Lissoclinum families of cyclic peptides found in marine organisms and algae.
Total syntheses and re-assignment of configurations of the cyclopeptides lissoclinamide 4 and lissoclinamide 5 from Lissoclinum patella
Boden, Christopher D.J.,Pattenden, Gerald
, p. 875 - 882 (2007/10/03)
The total synthesis of lissoclinamide 4 and lissoclinamide 5, which are novel oxazoline/thiazole/thiazoline-based cyclopeptides isolated from the ascidian ("sea squirt") Lissoclinum patella, are described. The synthesis of the bis-thiazole based lissoclin
Total Synthesis of Lissoclinamide 5, a Cytotoxic Cyclic Peptide from the Tunicate Lissoclinum patella
Boden, Christopher,Pattenden, Gerald
, p. 8271 - 8274 (2007/10/02)
A total synthesis of lissoclinamide 5, and some of its stereoisomers, shows that its stereostructure should be revised to 13.
Synthetic studies towards cyclic peptides. Concise synthesis of thiazoline and thiazole containing amino acids
North, Michael,Pattenden, Gerald
, p. 8267 - 8290 (2007/12/18)
Concise and efficient syntheses of optically pure thiazoline and thiazole containing amino acids of the constitution (26) and (27), based on simple condensation reactions between cysteine esters and N-protected imino ethers (22) and (25) derived from chir
