132475-86-6

Upstream product

• 125066-15-1 2-(phenylsulfonylmethyl)cyclohexenone 
• 79-24-3 Nitroethane 
• 106281-44-1 (6-oxocyclohex-1-en-1-yl)methyl acetate 
• 105956-40-9 2-(hydroxymethyl)cyclohex-2-en-1-one 
• 930-68-7 cyclohexenone 
• 76047-55-7 2--2-cyclohexenone 
• 113526-04-8 2-(nitromethyl)-cyclohex-1-ene-3-one 

Downstream Products

• 33553-25-2 2-(2-oxopropyl)cyclohex-2-en-1-one 

Relevant academic research and scientific papers

Regiospecific reaction of stabilized carbanions with 2-(acetoxymethyl)-2-cyclohexenone 1: Synthesis of bicyclic dienones

Regiospecific replacement of acetoxy group in 2-(acetoxymethyl)-2-cyclohexenone 1 by stabilizedd carbanions, leads to S(N) 2-type products 2a-g, 5 and 6. Bicyclic dienones 4 are prepared in 'one pot' from the reaction of 2 with K2CO3 in refluxing absolute ethanol.

Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor

A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying the substrates, the substituents, or the heating mode, it is possible to selectively synthesize indole, indolone (1,5,6,7-tetrahydroindol-4-one), or cinnoline (5,6,7,8-tetrahydrocinnoline) derivatives in moderate to excellent yields.

Regioselective replacement of nitro or sulfonyl group in cyclic α-(nitroalkyl)- or α-(phenylsulfonylalkyl)enones by nucleophiles

Cyclic α-(nitroalkyl)enones and α-(phenylsulfonylalkyl)enones undergo regioselective substitution of the nitro group by relatively soft sulfur, nitrogen and carbon nucleophiles.