33553-25-2

Upstream product

• 105956-40-9 2-(hydroxymethyl)cyclohex-2-en-1-one 
• 106281-44-1 (6-oxocyclohex-1-en-1-yl)methyl acetate 
• 132475-86-6 2-(2-nitropropyl)cyclohex-2-en-1-one 
• 94319-63-8 C₈H₁₀O₂S 
• 930-68-7 cyclohexenone 
• 94319-62-7 2-(prop-2-yn-1-yl) cyclohex-2-enone 
• 139278-54-9 2-(triisopropylsiloxy)-1,3-butadiene 
• 765-87-7 cyclohexane-1,2-dione 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 2684-62-0 diazoacetone 
• 2161-90-2 1-methoxy-1,3-cyclohexadiene 

Downstream Products

• 17901-58-5 1-benzyl-2-methyl-1H-indole 
• 93007-96-6 1-benzyl-2-methyl-1,5,6,7-tetrahydro-4H-indol-4-one 
• 6126-53-0 2-(2-oxopropyl)cyclohexanone 

Relevant academic research and scientific papers

Tuneable access to indole, indolone, and cinnoline derivatives from a common 1,4-diketone Michael acceptor

A convergent strategy is reported for the construction of nitrogen-containing heterocycles from common substrates: 1,4-diketones and primary amines. Indeed, by just varying the substrates, the substituents, or the heating mode, it is possible to selectively synthesize indole, indolone (1,5,6,7-tetrahydroindol-4-one), or cinnoline (5,6,7,8-tetrahydrocinnoline) derivatives in moderate to excellent yields.

Formal syntheses of (±)-platensimycin and (±)-platencin via a dual-mode lewis acid induced cascade cyclization approach

A mild and efficient dual-mode Lewis acid induced Diels-Alder (DA)/carbocyclization cascade cyclization reaction has been developed for construction of the tricyclic core of ent-kaurenoids in one pot with the aid of a theoretical study on the π,σ-Lewis acidities of a variety of Lewis acids. With ZnBr2 as the dual-mode Lewis acid, a series of substituted enones and dienes underwent DA/carbocyclization cascade cyclization reaction smoothly at room temperature and provided the tricyclic cyclized products in one pot with good yields and high diastereoselectivity. The tricyclic cyclized product has been successfully utilized as a common intermediate for formal syntheses of (±)-platensimycin and (±)-platencin.

Solvent effects in reactions of diketones with Wittig and Wittig-Horner reagents

In a series of reactions between Wittig or Wittig-Horner (Wadsworth-Emmons) reagents and diketones it was found that out of the five solvents tested, for the Wittig reagents, namely dichloromethane, toluene, ethanol, dimethylformamide, and pyridine, only