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Usage

Uses

Used in Agriculture:
2-(Trifluoromethyl)-1H-indole-3-acetic acid is used as a plant growth regulator for its auxin-like activity, which can mimic the effects of natural plant hormones and promote plant growth and development.
Used in Pharmaceutical Development:
2-(Trifluoromethyl)-1H-indole-3-acetic acid is used as a potential candidate for the development of new pharmaceuticals due to its antioxidant and anti-inflammatory properties, which may have therapeutic applications in medicine.

InChI:InChI=1/C11H8F3NO2/c12-11(13,14)10-7(5-9(16)17)6-3-1-2-4-8(6)15-10/h1-4,15H,5H2,(H,16,17)

Upstream product

• 174907-40-5 2-(2-(trifluoromethyl)-1H-indol-3-yl)acetonitrile 
• 87-51-4 indole-3-acetic acid 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 174907-42-7 N,N-dimethyl-1-(2-(trifluoromethyl)-1H-indol-3-yl)methanamine 
• 51310-54-4 2-(trifluoromethyl)indole 
• 154875-87-3 N-(2-ethylphenyl)-2,2,2-trifluoroacetimidoyl chloride 
• 578-54-1 ortho-ethylaniline 
• 929075-62-7 [3-(bromomethyl)-2-(trifluoromethyl)-1H-indol-1-yl](4-chlorophenyl)methanone 
• 913955-36-9 (4-chloro-phenyl)[3-methyl-2-(trifluoromethyl)-1H-indol-1-yl]-methanone 
• 913955-35-8 3-methyl-2-(trifluoromethyl)-1H-indole 
• 913962-14-8 N-[2-(1-bromoethyl)phenyl]-2,2,2-trifluoroacetimidoyl chloride 
• 75-63-8 Bromotrifluoromethane 
• 80586-67-0 indole-3-acetic acid tetramethylammonium salt 

Relevant academic research and scientific papers

Grignard cyclization reaction of fluorinated N-arylimidoyl chlorides: A novel and facile access to 2-fluoroalkyl indoles

2-Fluoroalkyl-substituted indole derivatives were simply prepared via the Grignard cyclization reaction (GCR) of corresponding fluorinated N-aryl imidoyl chlorides in good yields. This approach provides a novel and facile access to the biologically import

Synthesis of several 3-substituted 2-trifluoromethylindoles via Mannich reaction of 2-trifluoromethylindoles

Several 2-trifluoromethyl derivatives of biologically active indoles, tryptamine, indole-3-acetic acid, oxypertine and tryptophan, were synthesized starting from 2-trifluoromethylindoles by use of the Mannich reaction and subsequent nucleophilic substitut

An electrochemical approach for the synthesis of perfluoroalkylated purine and indole analogues of plant growth regulators

In an effort to prepare new fluorine-containing molecules as analogues of Plant Growth Regulators (PGRs), the indirect electrochemical reduction, by means of an aromatic anion mediator, of perfluoroalkyl halides in the presence of purine and indolyl anion

Fluorinated N-[2-(haloalkyl)phenyl]imidoyl chloride, a key intermediate for the synthesis of 2-fluoroalkyl substituted indole derivatives via Grignard cyclization process

Fluorinated N-[2-(haloalkyl)phenyl]imidoyl chloride, which was readily available from the corresponding anilines by using Uneyama's one-pot synthesis of fluorinated imidoyl chloride, was found to be a key intermediate for the facile synthesis of 2-fluoroa

Exploring the Structure and Performance of Cd–Chalcogenide Photocatalysts in Selective Trifluoromethylation

The field of heterogeneous photoredox catalysis has grown substantially and impacted organic synthesis because of the affordability and reusability of catalysts. This study reports radical trifluoromethylation with Cd–chalcogenide semiconductors. Cd semiconductors, particularly CdSe, are readily available, commercial, visible-light-responsive, heterogeneous photocatalysts. The potential of readily available Cd semiconductors, particularly CdSe, is confirmed by their increased photocatalytic activity toward trifluoromethylation with various substrates, such as (hetero)arenes and vinylic amides/acids, via addition, cyclization, and decarboxylation under visible light. The economic significance of this strategy is also highlighted through the scalable synthesis of biologically active molecules followed by catalyst reuse. Moreover, these catalysts are relatively inexpensive compared with transition metal-based homogeneous photocatalysts, presently used in organic synthesis.