132502-93-3

Basic information

• Product Name: 2-(Trifluoromethyl)-1H-indole-3-acetic acid
• Synonyms: 2-(2-(Trifluoromethyl)-1H-indol-3-yl)acetic acid;2-(Trifluoromethyl)-1H-indole-3-acetic acid;[2-(trifluoromethyl)-1H-indol-3-yl]acetic acid
• CAS NO: 132502-93-3
• Molecular Formula: C11H8F3NO2
• Molecular Weight: 243.18
• Mol File: 132502-93-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 387.3 °C at 760 mmHg
• Flash Point: 188 °C
• Appearance: /
• Density: 1.493
• Vapor Pressure: 1.08E-06mmHg at 25°C
• Refractive Index: 1.585
• CAS DataBase Reference: 2-(Trifluoromethyl)-1H-indole-3-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Trifluoromethyl)-1H-indole-3-acetic acid(132502-93-3)
• EPA Substance Registry System: 2-(Trifluoromethyl)-1H-indole-3-acetic acid(132502-93-3)

Safety Data

• Hazardous Substances Data: 132502-93-3(Hazardous Substances Data)

Usage

General Description

2-(Trifluoromethyl)-1H-indole-3-acetic acid is a synthetic chemical compound that belongs to the family of indole-3-acetic acids. It is a derivative of indole-3-acetic acid and has a trifluoromethyl group attached to the 2-position of the indole ring. 2-(Trifluoromethyl)-1H-indole-3-acetic acid has been studied for its potential use in agriculture as a plant growth regulator, as well as in the development of new pharmaceuticals. It is known to exhibit auxin-like activity, which means it can mimic the effects of natural plant hormones. Research has also shown that it may have antioxidant and anti-inflammatory properties, making it a compound of interest for various potential applications in the fields of agriculture and medicine.

InChI:InChI=1/C11H8F3NO2/c12-11(13,14)10-7(5-9(16)17)6-3-1-2-4-8(6)15-10/h1-4,15H,5H2,(H,16,17)

Upstream product

• 87-51-4 indole-3-acetic acid 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 174907-42-7 N,N-dimethyl-1-(2-(trifluoromethyl)-1H-indol-3-yl)methanamine 
• 51310-54-4 2-(trifluoromethyl)indole 
• 154875-87-3 N-(2-ethylphenyl)-2,2,2-trifluoroacetimidoyl chloride 
• 578-54-1 ortho-ethylaniline 
• 929075-62-7 [3-(bromomethyl)-2-(trifluoromethyl)-1H-indol-1-yl](4-chlorophenyl)methanone 
• 913955-36-9 (4-chloro-phenyl)[3-methyl-2-(trifluoromethyl)-1H-indol-1-yl]-methanone 
• 913955-35-8 3-methyl-2-(trifluoromethyl)-1H-indole 
• 913962-14-8 N-[2-(1-bromoethyl)phenyl]-2,2,2-trifluoroacetimidoyl chloride 
• 75-63-8 Bromotrifluoromethane 
• 80586-67-0 indole-3-acetic acid tetramethylammonium salt 
• 174907-40-5 2-(2-(trifluoromethyl)-1H-indol-3-yl)acetonitrile 

Relevant articles and documents

Grignard cyclization reaction of fluorinated N-arylimidoyl chlorides: A novel and facile access to 2-fluoroalkyl indoles

2-Fluoroalkyl-substituted indole derivatives were simply prepared via the Grignard cyclization reaction (GCR) of corresponding fluorinated N-aryl imidoyl chlorides in good yields. This approach provides a novel and facile access to the biologically import

An electrochemical approach for the synthesis of perfluoroalkylated purine and indole analogues of plant growth regulators

In an effort to prepare new fluorine-containing molecules as analogues of Plant Growth Regulators (PGRs), the indirect electrochemical reduction, by means of an aromatic anion mediator, of perfluoroalkyl halides in the presence of purine and indolyl anion

Exploring the Structure and Performance of Cd–Chalcogenide Photocatalysts in Selective Trifluoromethylation

The field of heterogeneous photoredox catalysis has grown substantially and impacted organic synthesis because of the affordability and reusability of catalysts. This study reports radical trifluoromethylation with Cd–chalcogenide semiconductors. Cd semiconductors, particularly CdSe, are readily available, commercial, visible-light-responsive, heterogeneous photocatalysts. The potential of readily available Cd semiconductors, particularly CdSe, is confirmed by their increased photocatalytic activity toward trifluoromethylation with various substrates, such as (hetero)arenes and vinylic amides/acids, via addition, cyclization, and decarboxylation under visible light. The economic significance of this strategy is also highlighted through the scalable synthesis of biologically active molecules followed by catalyst reuse. Moreover, these catalysts are relatively inexpensive compared with transition metal-based homogeneous photocatalysts, presently used in organic synthesis.