132567-64-7Relevant academic research and scientific papers
A green and practical one-pot two-step strategy for the synthesis of symmetric 3,6-diarylpyridazines
Rimaz, Mehdi,Mousavi, Hossein,Khalili, Behzad,Aali, Farkhondeh
, p. 1389 - 1397 (2018/11/26)
A simple, mild, and efficient synthesis of symmetric 3,6-diarylpyridazine derivatives using a green catalytic one-pot two-step reaction of aryl methyl ketones, arylglyoxal monohydrates, and hydrazine hydrate was developed. Environmentally benign nature, high atom-economy, no harmful byproduct, easy workup procedure, no column chromatography steps, and moderate to excellent yields of the products are the salient features of this new multicomponent-based methodology.
A novel coupling reaction of α-halo ketones promoted by SmI3/CuI
Liu, Yongjun,Zhao, Hengmin,Tian, Guang,Du, Feng,Qi, Yan,Wen, Yonghong
, p. 26317 - 26322 (2016/03/25)
With SmI3 as the Lewis acid and catalyzed by CuI in DMF, α-haloketones were transformed unexpectedly into α-hydroxy-1,4-diketones in good to moderate yields. The mechanism was probed and a plausible reaction pathway was proposed. DMF was assumed to play a dual role both as a hydroxyl source and as a solvent.
DABCO-catalyzed green synthesis of 2-Hydroxy-1,4-diones via direct aldol reaction of arylglyoxals in water
Saraei, Mahnaz,Eftekhari-Sis, Bagher,Mozaffarnia, Sakineh
, p. 252 - 259 (2013/07/26)
A green and simple method to synthesize of 1,4-diketones via aldol reaction of arylglyoxals and ketones such as 1-(4-methoxyphenyl)-2-propanone, deoxybenzoin and substituted acetophenones in the presence of a catalytic amount of DABCO in water at room temperature has been reported. Corresponding 2-hydroxy-1,4-diones were obtained in moderate to high yields with simple separation of obtained solid from reaction mixture and recrystallization.
