34102-85-7

Upstream product

• 97556-23-5 3,6-bis(4-bromophenyl)-2,7-dihydro-1,4,5-thiadiazepine 
• 64-17-5 ethanol 
• 6332-09-8 1.4-bis-(4-bromo-phenyl)-butene-(2c)-dione-(1.4) 
• 7803-57-8 hydrazine hydrate 
• 64-19-7 acetic acid 
• 128256-28-0 C₁₄H₁₂Br₂N₂O₂S 
• 132567-64-7 1,4-bis(4-bromophenyl)-2-hydroxybutane-1,4-dione 
• 80352-42-7 1-(4-bromophenyl)-2,2-dihydroxyethanone 
• 99-90-1 para-bromoacetophenone 
• 58881-56-4 2,2'-thiobis[1-(4-bromophenyl)ethanone] 
• 1777-57-7 p-bromobenzoylmethylenetriphenylphosphorane 

Downstream Products

• 73550-85-3 2,5-bis-(4'-cyanophenyl)-pyridazine 

Relevant academic research and scientific papers

A green and practical one-pot two-step strategy for the synthesis of symmetric 3,6-diarylpyridazines

A simple, mild, and efficient synthesis of symmetric 3,6-diarylpyridazine derivatives using a green catalytic one-pot two-step reaction of aryl methyl ketones, arylglyoxal monohydrates, and hydrazine hydrate was developed. Environmentally benign nature, high atom-economy, no harmful byproduct, easy workup procedure, no column chromatography steps, and moderate to excellent yields of the products are the salient features of this new multicomponent-based methodology.

Degradational cyclization of α-[2-phenyl-2- (phenylsulfonylhydrazono)ethyl]phenacylidenetriphenylphosphoranes to 3,6- diphenylpyridazines and 5-benzoyl-3-phenylpyrazoles

α-[2-Phenyl-2- (phenylsulfonylhydrazono)ethyl]phenacylidenetriphenylphosphoranes were obtained (60-71%) by the reaction between phenylsulfonylhydrazones of phenacyl bromides and phenacylidenetriphenylphosphoranes. Thermolysis of the phosphoranes gave 3,6-diphenylpyridazines (43-66%) and 5-benzoyl-3- phenylpyrazoles (13-27%), together with triphenylphosphine oxide and S-phenyl benzenethiosulfonate, a disproportionation product from benzenesulfinic acid. The structure of the intermediate α-substituted phenacylidenetriphenylphosphorane was confirmed by an X-Ray diffraction method.

Preparation of 3,6-Disubstituted Pyridazines from 3-Thiapentane-1,5-diones via 2,7-Dihydro-1,4,5-thiadiazepines

A series of 3-thiapentane-1,5-diones condense with hydrazine in the presence of a catalytic amount of p-toluenesulfonic acid in refluxing ethanol to give 2,7-dihydro-1,4,5-thiadiazepines in excellent yields.Thermal decomposition of the latter compounds in

A CONVENIENT SYNTHESIS OF 3,6-DIARYLPYRIDAZINES

Cathodic reductions of phenacylbromides semicarbazones lead to 1,4-diaryl-1,4-butanedione disemicarbazones which give the corresponding 3,6-diarylpyridazines directly by heating.