13273-57-9

Basic information

• Product Name: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-phenyl-
• CAS NO: 13273-57-9
• Molecular Formula: C14H9ClN2O
• Molecular Weight: 256.691
• Mol File: 13273-57-9.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-phenyl-(13273-57-9)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-phenyl-(13273-57-9)

Safety Data

• Hazardous Substances Data: 13273-57-9(Hazardous Substances Data)

Upstream product

• 87277-55-2 N-[1-(4-Chloro-phenyl)-1-methoxy-meth-(Z)-ylidene]-benzamide 
• 201230-82-2 carbon monoxide 
• 5033-28-3 4-chlorobenzamidoxime 
• 144930-53-0 (4-bromophenyl)(phenyl)iodonium triflate 
• 623-03-0 4-Cyanochlorobenzene 
• 98-88-4 benzoyl chloride 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 1257542-98-5 4-chloro-N'-hydroxybenzimidamide 
• 2579-22-8 Phenylpropargyl aldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 100-46-9 benzylamine 
• 65-85-0 benzoic acid 
• 5033-28-3 4-chloro-N-hydroxybenzimidamide 
• 10550-15-9 3-(4-chlorophenyl)-1,2,4-oxadiazole 

Relevant articles and documents

Manganese oxide nanoparticles supported on graphene oxide as an efficient nanocatalyst for the synthesis of 1,2,4-oxadiazoles from aldehydes

The easy synthesis of graphene oxide (GO)-supported manganese dioxide (MnO2) nanoparticles as a stable heterogeneous nanocatalyst (MnO2@GO) is described. This catalyst was investigated in the synthesis of 1,2,4-oxadiazoles from amido

Magnesia-supported hydroxylamine hydrochloride in the presence of sodium carbonate as an efficient reagent for the synthesis of 1,2,4-oxadiazoles from nitriles

An efficient one-pot method has been developed for the synthesis of 1,2,4-oxadiazoles through a one-pot reaction of nitriles with hydroxylamine hydrochloride in the presence of magnesia-supported sodium carbonate followed by reaction with acyl halides under solvent-free conditions using microwave irradiation. This method is easy, rapid and good yielding.

Hypervalent iodine in synthesis. 75. A convenient synthesis of oxadiazoles by palladium-catalyzed carbonylation and cyclization of diaryliodonium salts and amidoximes

3,5-Disubstituted-1,2,4-oxadiazoles were prepared in one-pot procedure in moderate yields via the palladium-catalyzed carbonylation of diaryliodonium salts with amidoximes under one atmosphere of carbon monoxide followed by intramolecular dehydrative cycl

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines

The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).