132769-57-4

Upstream product

• 90921-36-1 4-phenyl-but-3-enoic acid amide 
• 122-78-1 phenylacetaldehyde 
• 372-09-8 cyanoacetic acid 
• 100-39-0 benzyl bromide 
• 107-13-1 acrylonitrile 
• 1209495-01-1 rac-1-cyano-3-phenylpropyl trifluoromethanesulfonate 
• 5720-05-8 4-methylphenylboronic acid 
• 60773-92-4 β-benzalpropionic acid chloride 
• 79265-03-5 Acetic acid (E)-1-cyano-3-phenyl-allyl ester 
• 104-53-0 3-phenyl-propionaldehyde 
• 433216-32-1 2-morpholino-4-phenylbutanenitrile 

Downstream Products

• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Catalytic sp3C-CN Bond Cleavage: Ni-Mediated Phosphorylation of Alkylnitriles

A direct phosphorylation of the sp3C-CN bond catalyzed by a nickel catalyst is disclosed. A wide range of primary nitriles readily coupled with secondary phosphine oxides to produce the corresponding phosphorylated products in high yields. As a key step, this new method was applied to the synthesis of anticancer drug Combretastatin-A4, significantly shortening its synthetic path.

A novel oxidative transformation of α-aminonitriles to amides

A novel oxidative transformation of α-aminonitriles to amides is reported. Oxidation of α-aminonitriles with peracid, followed by basic treatment affords, amides in good yields. A mechanistic aspect of this transformation is also discussed.

C-C Bond Formation via Carbon-Centered Radicals Generated from Dicarbonyl(η5-cyclopentadienyl)organoiron Complexes

Irradiation of benzyldicarbonyl(η5-cyclopentadienyl)iron complex (2) leads to homolytic cleavage of the Fe-C bond.In the presence of activated alkenes, radical addition occurs, and both saturated and unsaturated addition products 7-9 are formed.Photolysis of alkyliron complexes 2, 3, and 20 in the presence of acrylonitrile leads to the same products as the irradiation of the respective acyliron complexes 28-30.This indicates that, under photolytical conditions, alkyl and acyl complexes are in equilibrium with each other.

Dimeric Metal Complexes as Mediator for Radical C-C Bond-Forming Reactions

Irradiation of dicarbonyl(η5-cyclopentadienyl)iron dimer 1 or decacarbonyldimanganese (2) in the presence of alkyl halides leads to C-centered radicals which can be trapped by alkenes and yields saturated and/or unsaturated addition products.Carbon radicals are generated via halogen abstraction by the initially formed metal-centered radicals resulting from homolysis of the metal-metal bond of dimeric mediators 1 and 2.No reaction occurs using octacarbonyl dicobalt (3).

ORGANO TIN NUCLEOPHILES III. PALLADIUM CATALYZED REDUCTIVE CLEAVAGE OF ALLYLIC HETEROSUBSTITUENTS WITH TIN HYDRIDE

Tributyl tin hydride, serving as an efficient hydride transfer agent, allows highly chemoselective palladium catalyzed reductions of allylic heterosubstituents even in presence of aldehydes, benzyl acetate and benzyl chloride.