79265-03-5

Upstream product

• 151-50-8 potassium cyanide 
• 108-24-7 acetic anhydride 
• 104-55-2 3-phenyl-propenal 
• 631-57-2 Acetyl cyanide 
• 61912-03-6 2-hydroxy-4-phenyl-3-butenenitrile 
• 143-33-9 sodium cyanide 

Downstream Products

• 16170-45-9 4-phenylbut-3-enenitrile 
• 83144-20-1 (E)-4-hydroxy-4-phenyl-2-butenenitrile 
• 13125-52-5 trans-1-phenyl-3-cyanoprop-2-en-1-one 
• 5343-98-6 4-oxo-4-phenylbutanenitrile 
• 83144-18-7 Acetic acid (Z)-3-cyano-1-phenyl-allyl ester 
• 83144-17-6 Acetic acid (E)-3-cyano-1-phenyl-allyl ester 
• 132769-57-4 4-phenyl-crotononitrile 
• 81981-19-3 (E)-4-Morpholin-4-yl-4-phenyl-but-2-enenitrile 

Relevant academic research and scientific papers

TBD- or PS-TBD-catalyzed one-pot synthesis of cyanohydrin carbonates and cyanohydrin acetates from carbonyl compounds

Cyanation reactions of carbonyl compounds with methyl cyanoformate or acetyl cyanide catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) were examined. Using methyl cyanoformate, the corresponding cyanohydrin carbonates were readily obtained in high yield for aromatic and aliphatic aldehydes and ketones. Similar results were obtained when acetyl cyanide was used as the cyanide source. The polymer-supported catalyst, PS-TBD, also acted as a good catalyst for this reaction. PS-TBD was easily recovered and reused with minimal activity loss.

Fast microwave-assisted resolution of (±)-cyanohydrins promoted by lipase from Candida antarctica

Enzymatic kinetic resolution (EKR) of (±)-cyanohydrins was performed by using immobilized lipase from Candida antarctica (CALB) under conventional ordinary conditions (orbital shaking) and under microwave radiation (MW). The use of microwave radiation contributed very expressively on the reduction of the reaction time from 24 to 2 h. Most importantly, high selectivity (up to 92percent eep) as well as conversion was achieved under MW radiation (50-56percent).

Zinc tetrafluoroborate-catalyzed efficient conversion of aldehydes to geminal diacetates and cyanoacetates

A trace of an aqueous solution of zinc tetrafluoroborate was demonstrated to catalyze the conversion of an aldehyde to its 1,1-diacetate by acetic anhydride without any solvent. A similar reaction of an aldehyde with a mixture of potassium cyanide and acetic anhydride in methylene chloride was also catalyzed by Zn(BF4)2 to provide the corresponding geminal cyanoacetate.