An efficient chemo-enzymatic approach to (+)-meroquinene

Article abstract of DOI:10.1016/S0957-4166(00)80445-0

Meroquinone (+)-1 was prepared in an efficient and stereocontrolled fashion from (-)-(1R-2S)-4-cyclohexene dimethanol monoacetate (-)-8. Key steps are the enzyme-catalyzed hydrolysis of the available diacetate 5 to (-)-8 and of the intermediate diester 17