133040-06-9

Basic information

• Product Name: Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate
• Synonyms: Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate;Eprosartan Dimethyl Ester;Eprosartan DiMethyl Diester
• CAS NO: 133040-06-9
• Molecular Formula: C₂₅H₂₈N₂O₄S
• Molecular Weight: 452.56582
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 133040-06-9.mol

Chemical Properties

• Boiling Point: 613.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: 6.12±0.50(Predicted)
• CAS DataBase Reference: Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate(133040-06-9)
• EPA Substance Registry System: Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate(133040-06-9)

Safety Data

• Hazardous Substances Data: 133040-06-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is used as a synthetic intermediate for the development of various organic compounds. Its unique structure and functional groups make it a versatile component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is used as a key component in the synthesis of novel drug candidates. Its incorporation into drug molecules can potentially enhance their therapeutic properties, such as improving bioavailability, targeting specific receptors, or exhibiting enhanced efficacy against certain diseases.
Used in Agrochemical Industry:
Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is also utilized in the agrochemical industry for the development of new pesticides, herbicides, and other crop protection agents. Its unique chemical structure can contribute to the creation of more effective and environmentally friendly products.
Used in Specialty Chemicals:
In the specialty chemicals sector, Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is employed as a building block for the synthesis of various high-value chemicals. These can include dyes, fragrances, and other additives used in a wide range of applications, from the textile industry to the cosmetics sector.

Upstream product

• 133040-03-6 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde 
• 133040-05-8 4-[5-(1-Acetoxy-2-methoxycarbonyl-3-thiophen-2-yl-propyl)-2-butyl-imidazol-1-ylmethyl]-benzoic acid methyl ester 
• 50790-93-7 2-butyl-1H-imidazole 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 133040-04-7 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole 
• 154371-61-6 2-butyl-4,5-diiodoimidazole 
• 146771-83-7 2-butyl-4-iodoimidazole-5-carboxaldehyde 
• 154371-62-7 1-(benzyloxymethyl)-2-butyl-4,5-diiodoimidazole 
• 154371-51-4 1-(benzyloxymethyl)-2-butyl-4-iodoimidazole-5-carboxaldehyde 
• 154371-54-7 2-butyl-1-(4-carbomethoxybenzyl)-4-iodoimidazole-5-carboxaldehyde 
• 16862-05-8 methyl 3-(2-thienyl)propanoate 
• 83857-96-9 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde 
• 133040-02-5 2-butyl-4-chloro-1-<(4-carbomethoxyphenyl)methyl>-1H-imidazole-5-carboxaldehyde 

Downstream Products

• 133040-01-4 eprosartan 
• 148674-52-6 4-[2-Butyl-5-((E)-2-cyano-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-benzonitrile 
• 133486-07-4 (E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide 
• 148674-39-9 SB 206328 

Relevant articles and documents

2-butyl-4-iodoimidazole-5-carboxaldehyde: A versatile intermediate for the synthesis of highly functionalized imidazoles

The facile preparation of 2-butyl-4-iodoimidazole-5-carboxaldehyde 1 is described. The versatility of this intermediate in the synthesis of highly functionalized imidazoles is demonstrated with the synthesis of two potent and selective angiotensin II rece

Potent Nonpeptide Angiotensin II Receptor Antagonists. 2. (1-Carboxybenzyl)imidazole-5-acrylic Acids

The further evolution of the imidazole-5-acrylic acid series of nonpeptide angiotensin II receptor antagonists is detailed (for Part 1, see: J.Med.Chem. 1992, 35, 3858).Modifications of the N-benzyl ring substitution were undertaken in an effort to mimic the Tyr4 residue of angiotensin II.Introduction of a p-carboxylic acid on the N-benzyl ring resulted in the discovery of compounds with nanomolar affinity for the receptor and good oral activity.SAR studies of these potent antagonists revealed that the thienyl ring, the (E)-acrylic acid, and the imidazole ring in addition to the two acid groups were important for high potency.Also, overlay comparisons of the parent diacid with both angiotensin II and a representative biphenylyltetrazole nonpeptide angiotensin II receptor antagonist are presented.The parent diacid analog, SKF 108566 or (E)-3--2-propenoic acid, is currently in clinical development for the treatment of hypertension.