133040-04-7

Basic information

• Product Name: 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole
• Synonyms: 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole
• CAS NO: 133040-04-7
• Molecular Weight: 470.59
• Mol File: 133040-04-7.mol

Chemical Properties

• CAS DataBase Reference: 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole(133040-04-7)
• EPA Substance Registry System: 2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole(133040-04-7)

Safety Data

• Hazardous Substances Data: 133040-04-7(Hazardous Substances Data)

Upstream product

• 133040-02-5 2-butyl-4-chloro-1-<(4-carbomethoxyphenyl)methyl>-1H-imidazole-5-carboxaldehyde 
• 83857-96-9 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde 
• 154371-54-7 2-butyl-1-(4-carbomethoxybenzyl)-4-iodoimidazole-5-carboxaldehyde 
• 154371-51-4 1-(benzyloxymethyl)-2-butyl-4-iodoimidazole-5-carboxaldehyde 
• 154371-62-7 1-(benzyloxymethyl)-2-butyl-4,5-diiodoimidazole 
• 146771-83-7 2-butyl-4-iodoimidazole-5-carboxaldehyde 
• 154371-61-6 2-butyl-4,5-diiodoimidazole 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 50790-93-7 2-butyl-1H-imidazole 
• 16862-05-8 methyl 3-(2-thienyl)propanoate 
• 133040-03-6 2-n-butyl-1-[(4-carbomethoxyphenyl)methyl]-1H-imidazol-5-carboxaldehyde 

Downstream Products

• 148674-52-6 4-[2-Butyl-5-((E)-2-cyano-3-thiophen-2-yl-propenyl)-imidazol-1-ylmethyl]-benzonitrile 
• 133486-07-4 (E)-3-<2-butyl-1-<(4-carboxamidophenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenamide 
• 148674-39-9 SB 206328 
• 133040-06-9 methyl (E)-3-<2-butyl-1-<(4-carbomethoxyphenyl)methyl>imidazol-5-yl>-2-(2-thienylmethyl)-2-propenoate 
• 133040-01-4 eprosartan 
• 133040-05-8 4-[5-(1-Acetoxy-2-methoxycarbonyl-3-thiophen-2-yl-propyl)-2-butyl-imidazol-1-ylmethyl]-benzoic acid methyl ester 

Relevant articles and documents

2-butyl-4-iodoimidazole-5-carboxaldehyde: A versatile intermediate for the synthesis of highly functionalized imidazoles

The facile preparation of 2-butyl-4-iodoimidazole-5-carboxaldehyde 1 is described. The versatility of this intermediate in the synthesis of highly functionalized imidazoles is demonstrated with the synthesis of two potent and selective angiotensin II rece

Potent Nonpeptide Angiotensin II Receptor Antagonists. 2. (1-Carboxybenzyl)imidazole-5-acrylic Acids

The further evolution of the imidazole-5-acrylic acid series of nonpeptide angiotensin II receptor antagonists is detailed (for Part 1, see: J.Med.Chem. 1992, 35, 3858).Modifications of the N-benzyl ring substitution were undertaken in an effort to mimic the Tyr4 residue of angiotensin II.Introduction of a p-carboxylic acid on the N-benzyl ring resulted in the discovery of compounds with nanomolar affinity for the receptor and good oral activity.SAR studies of these potent antagonists revealed that the thienyl ring, the (E)-acrylic acid, and the imidazole ring in addition to the two acid groups were important for high potency.Also, overlay comparisons of the parent diacid with both angiotensin II and a representative biphenylyltetrazole nonpeptide angiotensin II receptor antagonist are presented.The parent diacid analog, SKF 108566 or (E)-3--2-propenoic acid, is currently in clinical development for the treatment of hypertension.