135248-89-4Relevant articles and documents
Peptide Tethering: Pocket-Directed Fragment Screening for Peptidomimetic Inhibitor Discovery
Arora, Paramjit S.,Marrone, Frank,Modell, Ashley E.,Panigrahi, Nihar R.,Zhang, Yingkai
supporting information, p. 1198 - 1204 (2022/02/05)
Constrained peptides have proven to be a rich source of ligands for protein surfaces, but are often limited in their binding potency. Deployment of nonnatural side chains that access unoccupied crevices on the receptor surface offers a potential avenue to
Disulfide-Based Protecting Groups for the Cysteine Side Chain
Albericio, Fernando,Chakraborty, Amit,De La Torre, Beatriz G.,Sharma, Anamika
supporting information, p. 9644 - 9647 (2020/12/21)
Two new disulfide-based protecting groups (SIT and MOT) are proposed for Cys thiol in the substitution of StBu, which is often difficult to remove. Both groups are based on a secondary thiol with a branched point in the β-position for an efficient modulat
VERSATILE PEPTIDE AND PROTEIN MACROCYCLIZATION AND MULTIMERIZATION WITH DIELS-ALDER CYCLOADDITIONS
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Paragraph 0141, (2020/10/21)
The present disclosure provides macrocyclic and macrobicyclic peptides with secondary structures that are stabilized over the corresponding non-cyclic peptides. The macrocyclic and macrobicyclic peptides are formed from peptides with adduct-forming, compl