13312-82-8Relevant academic research and scientific papers
A metalloligand appended with thiazole rings: Heterometallic {Co3+-Zn2+} and {Co3+-Cd2+} complexes and their heterogeneous catalytic applications
Bansal, Deepak,Hundal, Geeta,Gupta, Rajeev
, p. 1022 - 1032 (2015)
This work describes a Co3+-based metalloligand containing appended thiazole rings and its reactions with secondary metal ions to produce heterometallic {Co3+-Zn2+} and {Co3+-Cd2+} complexes. Structural studies show that some of the appended thiazole rings from the metalloligand coordinate to secondary metal ions, whereas the remaining ones act as hydrogen-bond acceptors to metal-bound CH3OH or H2O molecules. These heterometallic complexes function as reusable heterogeneous catalysts for the ring-opening reactions of epoxides as well as cyanation and Knoevenagel condensation reactions of aldehydes. The catalytic results illustrate that the microenvironment remains intact during the catalysis and potentially enhances the substrate interaction with the Lewis acidic secondary metal ions.
Constructing a triangular metallacycle with salen-Al and its application to a catalytic cyanosilylation reaction
Li, Bo,Li, Yang,Qiu, Huayu,Xu, Jun,Yin, Shouchun,Zhang, Jinjin,Zhang, Pengfei,Zhang, Yueyue
supporting information, p. 10399 - 10402 (2021/10/12)
A triangular metallosalen-based metallacycle was constructed in quantitative yield by the self-assembly of a 180° bis(pyridyl)salen-Al complex and a 60° diplatinum(ii) acceptor in a 1?:?1 stoichiometric ratio. This metallacycle was then successfully used to cyanosilylate a wide range of benzaldehydes with trimethylsilyl cyanide.
A magnetic nanoparticle catalyzed eco-friendly synthesis of cyanohydrins in a deep eutectic solvent
Azizi, Najmedin,Rahimi, Zahra,Alipour, Masoumeh
, p. 61191 - 61198 (2015/07/28)
Magnetic Fe3O4 nanoparticles in deep eutectic solvents (DESs) have been regard as excellent catalysts for highly efficient cyanosilylation of various aldehydes and epoxides using trimethylsilyl cyanide TMSCN in high yields with excellent selectivity. Fe3O4 nanoparticles were synthesized and applied as a catalyst for the preparation of a wide variety of cyanohydrins (α-hydroxy nitriles and β-hydroxy nitriles) in readily available urea-choline chloride deep eutectic solvent DES as the most promising environmentally benign and cost-effective green solvent. Magnetic DES operates at very mild reaction conditions and can be easily recycled without significant loss of its catalytic activity.
Mononuclear complexes of amide-based ligands containing appended functional groups: Role of secondary coordination spheres on catalysis
Bansal, Deepak,Kumar, Gulshan,Hundal, Geeta,Gupta, Rajeev
, p. 14865 - 14875 (2015/02/19)
Amide-based ligands H2L1, H2L2 and H2L3 containing thiazole, thiazoline and benzothiazole appended groups have been used to synthesize Zn2+ (1 and 3), Cd2+ complexes (2 and 4), and a Mn2+ complex (5). In all cases, potentially multidentate ligands create a meridional N3 coordination environment around the M(ii) ion whereas additional sites are occupied by labile nitrate ions in 1-4 and MeOH in 5. Interestingly, metal complexation caused the migration of protons from amidic N-H sites to the appended heterocyclic rings in complexes 1-4. Structural studies show that the protonated heterocyclic rings in these complexes create a hydrogen bond based cavity adjacent to the metal ion. Importantly, binding studies confirm that the substrates are bound within the complex cavity closer to the Lewis acidic metal in all complexes including the oxidation-sensitive Mn ion in complex 5. All complexes have been utilized as the reusable and heterogeneous catalysts for ring-opening reactions of assorted epoxides, cyanation reactions of various aldehydes, and epoxidation reactions of several olefins. This journal is
Three-dimensional {Co3+-Zn2+} and {Co 3+-Cd2+} networks originated from carboxylate-rich building blocks: Syntheses, structures, and heterogeneous catalysis
Kumar, Girijesh,Gupta, Rajeev
, p. 10773 - 10787 (2013/10/22)
The present work shows the utilization of Co3+ complexes appended with either para- or meta-arylcarboxylic acid groups as the molecular building blocks for the construction of three-dimensional {Co 3+-Zn2+} and {Co3+-Cd2+} heterobimetallic networks. The structural characterizations of these networks show several interesting features including well-defined pores and channels. These networks function as heterogeneous and reusable catalysts for the regio- and stereoselective ring-opening reactions of various epoxides and size-selective cyanation reactions of assorted aldehydes.
Enzymatic kinetic resolution of racemic cyanohydrins via enantioselective acylation
Xu, Qing,Xie, Yongli,Geng, Xiaohong,Chen, Peiran
supporting information; experimental part, p. 624 - 630 (2010/09/07)
Enzymatic kinetic resolution of a series of aromatic and aliphatic cyanohydrins in organic media has been investigated. The behavior of potential lipases, molecular sieves, acyl reagent, reaction temperature, and organic solvents on the kinetic resolution was studied. The influence of substrate structure, steric, and electronic nature and position of the aryl substituent on the enantioselectivity was discussed. Under the optimized reaction conditions, good enantioselectivity could be achieved for most of the investigated compounds. Specifically, substrates 1a, 1c, 1d, 1f, 1u could be resolved with the kinetic enantiomer ratio (E) higher than 200.
A new (R)-hydroxynitrile lyase from Prunus mume: Asymmetric synthesis of cyanohydrins
Nanda, Samik,Kato, Yasuo,Asano, Yasuhisa
, p. 10908 - 10916 (2007/10/03)
A new hydroxynitrile lyase (HNL) was isolated from the seed of Japanese apricot (Prunus mume). The enzyme has similar properties with HNL isolated from other Prunus species and is FAD containing enzyme. It accepts a large number of unnatural substrates (benzaldehyde and its variant) for the addition of HCN to produce the corresponding cyanohydrins in excellent optical and chemical yields. A new HPLC based enantioselective assay technique was developed for the enzyme, which promotes the addition of KCN to benzaldehyde in a buffered solution (pH=4.5).
Catalysis of aldehyde and imine silylcyanation by platinum and palladium NCN-pincer complexes
Fossey, John S.,Richards, Christopher J.
, p. 8773 - 8776 (2007/10/03)
The room temperature addition of trimethylsilylcyanide to aromatic and aliphatic aldehydes to give the corresponding cyanohydrins is efficiently catalysed by 1 mol% of ((2,6-bis(N-cyclohexyl)imino)phenyl)aquoplatinum(II) trifluoromethanesulfonate 1a. This methodology is also applicable to the addition of trimethylsilylcyanide to Schiff bases resulting in the formation of α-amino nitriles.
3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
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, (2008/06/13)
Compounds of formula (I), their salts and prodrugs thereof, where the substituents are as defined herein are disclosed as opiate binding agents useful in the treatment of opiate-mediated conditions. Also described are processes for making such substances.
Synthesis and antimicrobial activity of some heterocyclic compounds
Trivedi, P. B.,Undavia, N. K.,Dave, A. M.,Bhatt, K. N.,Desai, N. C.
, p. 497 - 500 (2007/10/02)
Condensation of 2-phenyl-3-(4-benzoyl hydride)-1,3-quinazolin-4(4H)-one (1) with various aldehydes gives 2-phenyl-3-(4-arylidene-benzoylhydrazide)-1,3-quinazolin-4(4H)-one (II), which on cycloaddition with mercaptoacetic acid yield 4-thiazolidinones (IIIa-o).Compound (I) on treatment with aromatic cyanohydrines and aryl isothiocyanates gives α-carbohydrazino nitriles of (IVa-m) and thiosemicarbazides (Va-l) respectively.The structures of III-V have been elucidated on the basis of their elemental analysis and spectral data.These compounds exhibit moderate to goodantibacterial and tuberculostatic activities.
