405267-73-4Relevant academic research and scientific papers
COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF
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Paragraph 00399-00400, (2021/08/06)
The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and G
METHODS OF PROMOTING BETA CELL PROLIFERATION
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Paragraph 00194, (2018/06/30)
The present disclosure provides methods of promoting proliferation of a pancreatic cell. The methods are useful for the treatment of diabetes and other diseases characterized by impaired glucose tolerance.
THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
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Paragraph 00466, (2016/04/20)
The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins. Compounds of the disclosure may be used
HETEROCYCLIC DERIVATIVES AS RORGAMMA MODULATORS
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Page/Page column 44, (2016/07/27)
The present invention provides novel compounds of formula (I) that are modulators of RORgamma. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgamma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, fibrotic diseases, or cholestatic diseases.
ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE
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Page/Page column 43-44, (2008/06/13)
Compounds of formula I are useful in treatment of diseases associated with the deposition of β-amyloid in the brain.
Analogs of M4 selective synthetic muscarinic receptor antagonists: Synthesis, binding and pharmacokinetic properties
Boehme, Thomas M.,Augelli-Szafran, Corinne E.,Hallak, Hussein,Schwarz, Roy D.
, p. 423 - 433 (2007/10/03)
Recently, highly selective M4 muscarinic receptor antagonists (e.g., PD 0320115) have been synthesized and pharmacologically characterized. One compound, PD 0298029 which was selected for in vivo testing, had low bioavailability (rat ~5%) and p
Fused ring system containing indole as M4 selective aza-anthracene muscarinic receptor antagonists
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, (2008/06/13)
Disclosed are compounds of the Formula I and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, wherein R1 is hydrogen, lower alkyl, COOR7, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted aryla
