13328-85-3

Upstream product

• 60-12-8 2-phenylethanol 
• 6000-59-5 glyoxalic acid monohydrate 
• 124-38-9 carbon dioxide 
• 1359987-56-6 tributyl(3,4-dihydro-1H-isochromen-1-yl)stannane 
• 298-12-4 Glyoxilic acid 
• 13328-86-4 methyl 3,4-dihydro-1H-isochromene-1-carboxylate 

Downstream Products

• 96292-92-1 isochroman-1-ylmethanol 
• 83501-36-4 N-Methyl-1-isochromancarboxanilid 
• 13328-86-4 methyl 3,4-dihydro-1H-isochromene-1-carboxylate 
• 1395894-42-4 N-[4-(butan-2-ylcarbamoyl)phenyl]isochroman-1-carboxamide 
• 1089958-80-4 ethyl 4-[4-(isochroman-1-ylcarbonylamino)benzoylamino]benzoate 
• 1395894-43-5 N-[4-(1-phenylcyclopentylmethylcarbamoyl)phenyl]isochroman-1-carboxamide 
• 896161-82-3 N-[4-(3-chloro-4-methylphenylcarbamoyl)-phenyl]isochroman-1-carboxamide 
• 896161-88-9 N-{4-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]phenyl}isochroman-1-carboxamide 
• 896161-94-7 N-[4-(pyridin-2-ylcarbamoyl)phenyl]isochroman-1-carboxamide 
• 896161-92-5 N-[4-(piperidin-1-ylcarbonyl)phenyl]isochroman-1-carboxamide 
• 1089959-17-0 4-(isochroman-1-ylcarbonylamino)benzoic acid 
• 1408397-42-1 C₁₇H₁₄ClNO₃ 
• 83501-56-8 1-Benzyl-1-isochromancarbaldehyd 

Relevant academic research and scientific papers

Α-hydroxyacid salt

PROBLEM TO BE SOLVED: To provide a novel method for manufacturing a salt of α-hydroxy acid as an intermediate for synthesizing α-hydroxy acid derivatives which promotes carboxylation promptly by the COsupplementation reaction even if the substrate having

Synthesis of arylglycine and mandelic acid derivatives through carboxylations of α-amido and α-acetoxy stannanes with carbon dioxide

Incorporation reactions of carbon dioxide (CO2) with N-Boc-α-amido and α-acetoxy stannanes were developed using CsF as a mild tin activator. Monoprotected α-amido stannanes could be used, and the corresponding arylglycine derivatives were obtained in moderate-to-high yields under 1 MPa (10 atm) of CO2 pressure. α-Acetoxy stannanes also underwent carboxylation to afford mandelic acid derivatives in excellent yields under ambient CO2 pressure. Both transformations enabled the synthesis of α-tertiary and α-quaternary carboxylic acid derivatives. In addition, the chirality of (S)-N-tert-butylsulfonyl-α- amido stannanes was transferred with up to 90% inversion of configuration at 100 °C.

Anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for preparation thereof

This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'--CH(OH)--CO,

Isochromanyl-penicillins

(R/S)-Isochroman-1-carboxylic acid (1) is resolved to its enantiomers and as well as these reacted with 6-aminopenicillanic acid to the title compounds 2. The activity of the new penicillin-derivatives against gram positive and gram negative bacteria is c