94530-20-8

Basic information

• Product Name: 2-Cyclopenten-1-one, 4-hydroxy-2-[(phenylmethoxy)methyl]-, (R)-
• CAS NO: 94530-20-8
• Molecular Formula: C13H14O3
• Molecular Weight: 218.252
• Mol File: 94530-20-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Cyclopenten-1-one, 4-hydroxy-2-[(phenylmethoxy)methyl]-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopenten-1-one, 4-hydroxy-2-[(phenylmethoxy)methyl]-, (R)-(94530-20-8)
• EPA Substance Registry System: 2-Cyclopenten-1-one, 4-hydroxy-2-[(phenylmethoxy)methyl]-, (R)-(94530-20-8)

Safety Data

• Hazardous Substances Data: 94530-20-8(Hazardous Substances Data)

Upstream product

• 7284-07-3 5,6-dideoxy-1,2-O-isopropylidene-α-D-xylo-hex-5-eno-furanose 
• 94530-14-0 6-O-benzyl-5-deoxy-1,2-O-isopropylidene-α-D-xylo-hexofuranose 
• 74152-54-8 5,6-dideoxy-1,2-O-isopropylidene-3-O-(1-methoxy-1-methyl ethyl)-α-D-xylo-hex-5-enofuranose 
• 74152-55-9 5-deoxy-1,2-O-isopropylidene-3-(1-methoxy-1-methyl ethyl)-α-D-xylo-hexofuranose 
• 100-39-0 benzyl bromide 
• 94530-12-8 3,5-dideoxy-1,2-O-isopropylidene-α-D-glycero-hex-4-enofuranose 
• 94530-15-1 6-O-benzyl-5-deoxy-1,2-O-isopropylidene-3-trifluoromethylsulphonyl-α-D-xylo-hexofuranose 
• 94530-13-9 6-O-benzyl-3,5-dideoxy-1,2-O-isopropylidene-α-D-glycero-hex-4-enofuranose 
• 668996-17-6 (1R,4S,5S)-5-((benzyloxy)methyl)-4-((4-methoxybenzyl)oxy)cyclopent-2-enol 
• 110567-21-0 (1S,2R)-2-(benzyloxymethyl)-1-hydroxy-3-cyclopentene 
• 133299-26-0 (1S,2R,3S,5R)-2-benzyloxymethyl-3-(4-methoxybenzyloxy)-6-oxabicyclo<3.1.0>hexane 
• 668996-14-3 (1S,2S,5R)-2-Benzyloxymethyl-6-oxa-bicyclo[3.1.0]hexan-3-one 
• 94530-17-3 (R)-6-O-benzyloxy-2-hydroxy-4-oxohexanal 
• 94530-16-2 6-O-benzyl-3,5-dideoxy-1,2-O-isopropylidene-α-D-glycero-hex-3-enofuranose 

Downstream Products

• 668996-15-4 (1S,4R)-2-Benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-cyclopent-2-enol 
• 668996-26-7 2-benzyloxymethyl-4-(tert-butyl-diphenyl-silanyloxy)-cyclopent-2-enone 
• 94530-19-5 (S)-4-hydroxy-2-benzyloxymethylcyclopent-2-en-1-one benzoate 
• 94530-18-4 (R)-4-hydroxy-2-benzyloxymethylcyclopent-2-en-1-one benzoate 

Relevant articles and documents

Novel 3′-deoxy analogs of the anti-HBV agent entecavir: Synthesis of enantiomers from a single chiral epoxide

A synthesis of novel 3′-deoxy analogs of the anti-HBV agent entecavir (BMS-200475) was devised using regioselective ring opening of suitable cyclopentene epoxides as the key step. This versatile approach afforded access to an enantiomeric pair of carbocyclic nucleosides from a single chiral intermediate.

Synthesis of (R)-4-Hydroxy-2-benzyloxymethylcyclopent-2-en-1-one from D-Glucose via Palladium(0)-catalysed Rearrangement of a Vinylic Epoxide Intermediate

The transformation of D-glucose into (R)-4-hydroxy-2-benzyloxymethylcyclopent-2-en-1-one (3), a potential chiral synthon for the antibiotic (-)-pentenomycin I (4), has been achieved via the intramolecular aldolisation-dehydration of the 2-hydroxy-4-oxo-aldehyde (9) which was obtained by two different routes, one of them involving palladium(0)-catalysed rearrangement of a vinylic epoxide intermediate.