1333154-77-0

Basic information

• Product Name: Amino-PEG8-azide
• Synonyms: Amino-PEG8-azide;Azido-PEG7-amine;N3-PEG7-NH2;Azido-dPEG(R)7-amine
• CAS NO: 1333154-77-0
• Molecular Formula: C16H34N4O7
• Molecular Weight: 394.46376
• Mol File: 1333154-77-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Amino-PEG8-azide(CAS DataBase Reference)
• NIST Chemistry Reference: Amino-PEG8-azide(1333154-77-0)
• EPA Substance Registry System: Amino-PEG8-azide(1333154-77-0)

Safety Data

• Hazardous Substances Data: 1333154-77-0(Hazardous Substances Data)

Usage

Description

Amino-PEG8-azide, also known as Azido-dPEG7-amine, is a heterobifunctional PEGylated linker with a reactive NH2 end group and an azide functional group for use in click chemistry reactions. It is a versatile molecule that has been utilized in various applications due to its unique properties and reactivity.

Uses

Used in Pharmaceutical Industry:
Amino-PEG8-azide is used as a linker for the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors. Its PEGylation enhances the solubility and stability of the inhibitors, potentially improving their pharmacokinetic properties and therapeutic efficacy.
Used in Diagnostics and Assay Development:
Amino-PEG8-azide is used as a component in the development of diagnostic assays. It helps in detecting assay interferences and increasing the dynamic range of the assays, leading to more accurate and reliable results.
Used in Bioconjugation and Drug Delivery:
Due to its reactive azide functional group, Amino-PEG8-azide can be employed in bioconjugation processes, allowing for the attachment of various biomolecules, such as proteins, peptides, or nucleic acids, to other molecules or surfaces. This property makes it useful in the development of drug delivery systems, where it can be used to attach therapeutic agents to targeting moieties or carriers, enhancing the specificity and efficacy of the drug delivery.
Used in Materials Science:
Amino-PEG8-azide can be utilized in the synthesis of functional materials, such as hydrogels or nanoparticles, for various applications, including drug delivery, tissue engineering, and sensing. The PEGylation of these materials can improve their biocompatibility, stability, and circulation time in biological systems.

Upstream product

• 938190-67-1 α-allyl-ω-(2-azidoethoxy)hexa(oxyethylene) 
• 26150-06-1 tetraethylene glycol monoallyl ether 
• 112-60-7 Tetraethylene glycol 
• 1446411-31-9 α-(2-azidoethyl)-ω-(formylmethoxy)hexa(oxyethylene) 
• 1422541-03-4 C₂₄H₃₆N₄O₉ 
• 352439-39-5 1-azido-23-(methylsulfonyl)oxy-3,6,9,12,15,18,21-heptaoxatricosane 
• 225523-86-4 α,ω-diazido,α,ω-dideoxy-octaethyleneglycol 
• 106481-21-4 3,6,9,12,15,18,21-heptaoxatricosane-1,23-diyl dimethanesulfonate 
• 352439-36-2 α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene) 
• 924895-57-8 23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl methanesulfonate 
• 5117-19-1 octaethylene glycol 

Downstream Products

• 1334172-75-6 α-(2-azidoethyl)-ω-(2-(5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido)ethoxy)hexa(oxyethylene) 
• 206265-96-5 tert-butyl (23-azido-3,6,9,12,15,18,21-heptaoxatricosyl)carbamate 

Relevant articles and documents

Controlled-length efficient synthesis of heterobifunctionalized oligo ethylene glycols

A set of heterobifunctional oligo ethylene glycols have been synthesized in a straightforward and stepwise manner starting from inexpensive, commercially available, tetraethylene glycol. Introduction of terminal allyl moieties followed by reductive ozonolysis allowed controlled elongation. Mono-allyl derivatives were used for the elongation with a functionalized moiety and for successive introduction of different functional groups on the chain terminal. Georg Thieme Verlag Stuttgart - New York.

A "Clickable" MTX Reagent as a Practical Tool for Profiling Small-Molecule-Intracellular Target Interactions via MASPIT

We present a scalable synthesis of a versatile MTX reagent with an azide ligation handle that allows rapid γ-selective conjugation to yield MTX fusion compounds (MFCs) appropriate for MASPIT, a three-hybrid system that enables the identification of mammalian cytosolic proteins that interact with a small molecule of interest. We selected three structurally diverse pharmacologically active compounds (tamoxifen, reversine, and FK506) as model baits. After acetylene functionalization of these baits, MFCs were synthesized via a CuAAC reaction, demonstrating the general applicability of the MTX reagent. In analytical mode, MASPIT was able to give concentration-dependent reporter signals for the established target proteins. Furthermore, we demonstrate that the sensitivity obtained with the new MTX reagent was significantly stronger than that of a previously used non-regiomeric conjugate mixture. Finally, the FK506 MFC was explored in a cellular array screen for targets of FK506. Out of a pilot collection of nearly 2000 full-length human ORF preys, FKBP12, the established target of FK506, emerged as the prey protein that gave the highest increase in luciferase activity. This indicates that our newly developed synthetic strategy for the straightforward generation of MFCs is a promising asset to uncover new intracellular targets using MASPIT cellular array screening.