352439-36-2

Basic information

• Product Name: alpha-Azido-omega-hydroxy octa(ethylene glycol)
• Synonyms: Azido-PEG (n=7);O-(2-Azidoethyl)heptaethylene glycol;3,6,9,12,15,18,21-heptaoxatricosan-1-ol,23-azide;23-Azido-3,6,9,12,15,18,21-Heptaoxatricosan-1-ol;3,6,9,12,15,18,21-Heptaoxatricosan-1-ol, 23-azido-;PEG8-azide;O-(2-Azidoethyl)heptaethylene glycol >=95% (oligomer purity);Azido-PEG8-alcohol
• CAS NO: 352439-36-2
• Molecular Formula: C₁₆H₃₃N₃O₈
• Molecular Weight: 395.44852
• Product Categories: Heterobifunctional PEG;Aliphatic Azides;Alkynes and Other Reagents;Azides;Building Blocks;Chemical Biology;Chemical Synthesis;Conjugation Chemistry: Azides;Nitrogen Compounds;Organic Building Blocks;PEG Azides;PEGylation
• Mol File: 352439-36-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: Soluble in Water, DMSO, DCM, DMF
• BRN: 8940056
• CAS DataBase Reference: alpha-Azido-omega-hydroxy octa(ethylene glycol)(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-Azido-omega-hydroxy octa(ethylene glycol)(352439-36-2)
• EPA Substance Registry System: alpha-Azido-omega-hydroxy octa(ethylene glycol)(352439-36-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 352439-36-2(Hazardous Substances Data)

Usage

Description

Azide-PEG8-alcohol is a click chemistry reagent with an azide(N3) and a terminal hydroxyl group. The azide group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The hydroxyl (OH) group enables further derivatization or replacement with other functional groups.

Uses

O-(2-Azidoethyl)heptaethylene glycol is used to synthesize oligo and poly(ethylene glycol) derivatives that are used as structural units of dendrimers, hydrogels, surface modifiers, self-assembling systems and molecular crosslinkers. This precursor is compatible for acetylene-azide click reactions.Some of the reported applications include:Synthesis of strain-stiffening hydrogels through self-assembly of oligomers fibres derived from Azido-PEG (n=7).Synthesis of biodegradable tetra-PEG hydrogels for drug delivery system.Synthesis of heterobifunctional oligo(ethylene glycol) linkers for bioconjugation and targeted drug delivery.Preparation of synthetic amphiphiles for programmed pH-dependent dispersions of carbon nanotubes (CNTs).Selective glycoprotein detection through allosteric click-imprinting by using a self-assembled monolayer developed from the above oligomer.Preparation of bioactivated quantum dot micelles containing fluorescent nanocrystals.

Upstream product

• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 
• 125274-16-0 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol 
• 168640-82-2 11-azido-3,6,9-trioxa-undecanyl p-toluenesulfonate 
• 77544-60-6 p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester 
• 112-60-7 Tetraethylene glycol 
• 886469-23-4 2-(2-{2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate 
• 938190-67-1 α-allyl-ω-(2-azidoethoxy)hexa(oxyethylene) 
• 26150-06-1 tetraethylene glycol monoallyl ether 
• 924895-57-8 23-hydroxy-3,6,9,12,15,18,21-heptaoxatricos-1-yl methanesulfonate 
• 5117-19-1 octaethylene glycol 
• 65883-12-7 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate 
• 134179-43-4 11-azide-1-{(methylsulfonyl)oxy}-3,6,9-trioxaundecane 

Downstream Products

• 1196732-52-1 3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-amine 
• 1196732-55-4 N-(2,4-dinitrophenyl)-3,6,9,12,15,18,21,24-octaoxaheptacos-26-yn-1-amine 
• 1196732-45-2 (S)-2-(3-((S)-1-carboxy-5-(4-(25-(2,4-dinitrophenylamino)-2,5,8,11,14,17,20,23-octaoxapentacosyl)-1H-1,2,3-triazol-1-yl)pentyl)ureido)pentanedioic acid 
• 1422541-00-1 C₂₃H₃₆N₄O₁₂ 
• 1333154-77-0 α-amino,ω-azido,α,ω-dideoxy-octaethyleneglycol 
• 1637297-21-2 59-azido-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontan-1-ol 
• 139729-28-5 23-amino-3,6,9,12,15,18,21-heptaoxatricosanoic acid 
• 1214319-92-2 27-azido-4,7,10,13,16,19,22,25-octaoxaheptacosanoic acid 
• 756526-04-2 1-amino-3,6,9.12,15,18,21,24-octaoxaheptacosan-27-oic acid 
• 868594-52-9 26-(fluoren-9-ylmethyloxycarbonylamino)-3,6,9,12,15,18,21,24-octaoxahexaeicosanoic acid 
• 857892-34-3 23-azido-3,6,9,12,15,18,21-heptaoxatricosyl 4-methylbenzenesulfonate 

Relevant articles and documents

Supramolecular compound nano-carrier as well as preparation method and application thereof

The invention discloses a supramolecular compound nano-carrier as well as a preparation method and application thereof, and relates to the technical field of polymer chemistry and biological detection engineering. According to the supramolecular compound nano-carrier disclosed by the invention, a two-dimensional nanosheet supramolecular structure system generated by self-assembly is driven by an anion induction effect, and a supramolecular compound nano-carrier is of a single-layer nanosheet supramolecular structure constructed by a highly-oriented one-dimensional nanorod. A hydrophobic perylene group part is used as a skeleton part for constructing the highly-oriented one-dimensional nanorod, and the charge density of a single-layer nanosheet can be regulated and controlled. The surface of the water-soluble multivalent hydrophilic part can be loaded with DNAzyme deoxyribozyme for specific detection of heavy metal ions through electrostatic interaction, and the water-soluble multivalent supramolecular compound nano sensor is constructed. Based on a fluorescence change mechanism caused by specific cutting of heavy metal ions, The fluorescence detection of the heavy metal ions in food and biological tissues is realized, and the detection effect of the heavy metal ions is greatly enhanced.

PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof

The invention provides a PROTAC compound represented by formula I and used for targeted degradation of IDO1, and a pharmaceutically acceptable salt, a hydrate or a solvate thereof. In the formula I, Xrepresents -CH2 or -C = O, Y represents -CH2 or -C= O, and n is a natural number from 2 to 9. The PROTAC compound for targeted degradation of the IDO1 has efficient activity of targeted degradation of the IDO1 protein.

Monodisperse polyethylene glycol “brushes” with enhanced lipophilicity, and thermo and plasma stability

A convenient strategy was developed for highly branched and multifunctionalized peptidic monodisperse polyethylene glycol “brushes”, which exhibit remarkable physicochemical and biological properties and potential as versatile biomaterials.