13332-18-8

Upstream product

• 67-56-1 methanol 
• 67285-79-4 N-(Bicyclo<4.1.0>hept-exo-7-yl)-N-nitrosoharnstoff 
• 152974-21-5 (dimethylamino)-p-tolyloxosulfonium methylide 
• 162521-13-3 7-bicyclo<4.1.0>heptyl trimethylsilyl ketone 
• 31397-60-1 7-Brom-7-trimethylsilylnorcaran 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 19093-22-2 1-(2-Iodo-cyclohexyl)-propan-2-one 
• 6126-53-0 2-(2-oxopropyl)cyclohexanone 

Relevant academic research and scientific papers

NON-FUSED THIOPHENE DERIVATIVES AND THEIR USES

The present invention relates to a new class of non-fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

Reaction of acylsilanes with sulfur ylides. Selective formation of silyl enol ethers or β-ketosilanes

The reaction of acylsilanes with sulfur ylides in THF results in the formation of the corresponding silyl enol ethers or β-ketosilanes. The relative ratio of these products varies with the ylide conditions and the stability of ylide used. It is noteworthy that silyl enol ethers were formed under the salt-free ylide conditions, and that β-ketosilanes were yielded in the presence of soluble inorganic salts in THF, selectively. The formation of both products would be interpreted in terms of the anionotropic and cationotropic rearrangements of silyl group in the reaction intermediate.

Deamination Reactions, 42. Addition of Diazocyclopropanes to Carbonyl Compounds

Diazocyclopropanes (6, 38, 57) were generated in equilibrium with cyclopropanediazonium ions by base-induced cleavage of the analogous nitrosoureas in methanol.Efficient trapping of the diazocyclopropanes occurred in dilute solution with a slight excess of carbonyl compounds.The reactivity of the resulting 1-(α-hydroxyalkyl)cyclopropanediazonium ions (10) depended strongly on the α-substituents.Pinacol rearrangements predominated with aldehyde adducts, the migratory aptitudes being H > Ph > CH3.These 1,2-shifts are thought to proceed with inversion at the terminus - the preferred exo-attack of acetaldehyde at 7-diazonorcarane (38) led to the endo-ketone 40.The major product derived from the acetone adduct 22 was the epoxide 26 whose reaction(s) with metanol were also examined.The intramolecular addition of 8-diazobicyclooctan-4-one (57) gave rise to 6-methoxybicyclooct-4-en-1-ol (60).Due to steric constraints, the intermediate 58 underwent exclusive cyclopropyl-allyl transformations (otherwise a minor reaction).