1333386-18-7

Upstream product

• 320-51-4 4-chloro-3-trifluoromethyl-aniline 
• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 5470-22-4 4-chloropicolinic acid 
• 399-95-1 4-amino-3-fluorophenol 
• 327-78-6 4-chloro-3-(trifluoromethyl)phenyl isocyanate 
• 220000-86-2 tert-butyl 4-chloropyridine-2-carboxylate 
• 1020173-15-2 tert-butyl 4-(4-amino-3-fluorophenoxy)picolinate 
• 1333390-56-9 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea 
• 871555-75-8 (4-chloro-3-trifluoromethylphenyl)carbamic acid phenyl ester 
• 1333489-01-2 phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate 
• 1187945-02-3 tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate 
• 1187945-05-6 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid 
• 1333489-02-3 methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate 
• 1189858-48-7 4-chloropyridinyl-2-(N-1',1',1'-trideuteromethylcarboxamide) 

Relevant academic research and scientific papers

Preparation deuterated diphenylurea (by machine translation)

The invention relates to a method for preparing deuterated diphenyl urea. Specifically, the invention provides an intermediate N-(1, 1, 1-3 deuterated methyl) benzo succinimide which can be used for preparing a deuterated diphenyl urea compound and an application of the intermediate in the preparation of the deuterated diphenyl urea compound. The method can be used for conveniently preparing the intermediate with the high purity and various deuterated diphenyl urea compounds in high efficiency.

PREPARATION METHOD OF FLUORO-SUBSTITUTED DEUTERATED DIPHENYLUREA

A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.

METHOD FOR PREPARING DEUTERATED DIPHENYLUREA

Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.

METHOD FOR PREPARING DEUTERATED DIPHENYLUREA

Disclosed are an intermediate compound of N-(1,1,1-trideuterated methyl)phthalimide, and its use in the preparation of deuterated diphenylurea derivative.