133345-86-5Relevant academic research and scientific papers
Design and synthesis of haptens for antibody catalyzed hydrolysis of organophosphoms nerve agents
Renard, Pierre-Yves,Vayron, Philippe,Taran, Frederic,Mioskowski, Charles
, p. 281 - 284 (1999)
Haptens bearing phosphorane and α-hydroxyphosphinate structures have been designed and synthesized for the selection of monoclonal antibodies with phosphatase like activity in order to detoxify highly toxic organophosphorus chemical weapons such as VX.
Phosphinic acid analogues of GABA. 1. New potent and selective GABA(B) agonists
Froestl,Mickel,Hall,Von Sprecher,Strub,Baumann,Brugger,Gentsch,Jaekel,Olpe,Rihs,Vassout,Waldmeier,Bittiger
, p. 3297 - 3312 (2007/10/02)
The antispastic agent and muscle relaxant baclofen 1 is a potent and selective agonist for bicuculline-insensitive GABA(B) receptors. For many years efforts to obtain superior GABA(B) agonists were unsuccessful. We describe the syntheses and biological pr
Substituted aminoalkylphosphinic acids
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, (2008/06/13)
P-substituted aminoalkylphosphinic acids of the formula STR1 wherein R denotes an optionally fluorinated methyl group, R1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R2 and R3 denote hydrogen or R2 denotes hydroxy, lower alkoxy or halogen and R3 is hydrogen or R2 and R3 together represent an oxo group, and their pharmaceutically acceptable salts are active as GABAB- agonists and can be used in the treatment of spinal spasticity, multiple sclerosis and cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain. They can be manufactured by methods known per se and suitable such methods are described.
