Design and synthesis of haptens for antibody catalyzed hydrolysis of organophosphoms nerve agents

DOI: 10.1016/S0040-4039(98)02396-X

Source and publish data:

Tetrahedron Letters p. 281 - 284 (1999)

Update date:2022-09-26

Topics:

Authors:

Renard, Pierre-Yves

Vayron, Philippe

Taran, Frederic

Mioskowski, Charles

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Article abstract of DOI:10.1016/S0040-4039(98)02396-X

Haptens bearing phosphorane and α-hydroxyphosphinate structures have been designed and synthesized for the selection of monoclonal antibodies with phosphatase like activity in order to detoxify highly toxic organophosphorus chemical weapons such as VX.

Full text of DOI:10.1016/S0040-4039(98)02396-X

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