133363-40-3Relevant academic research and scientific papers
Conformationally constrained trytophan analogs, synthesis of (±)-(Z)- and (±)-(E)-2-amino-2,3-methano-3-(indol-3-yl)-propanoic acids
Donati, Daniele,Garzon-Aburbeh, Aaron,Natalini, Benedetto,Marchioro, Carla,Pellicciari, Roberto
, p. 9901 - 9908 (1996)
The syntheses of (±)-(Z)- and (±)-(E)-2-amino-2,3-methano-3-(indol- 3-yl)-propanoic acids (8 and 15) and reported. Key step in their preparation is the cyclopropanation of an olefinic azlactone derivative, followed by suitable deprotection sequence.
Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents
Roaiah, Hanaa M.,Ghannam, Iman A. Y.,Ali, Islam H.,El Kerdawy, Ahmed M.,Ali, Mamdouh M.,Abbas, Safinaz E-S.,El-Nakkady, Sally S.
, (2018/01/22)
A series of new indole derivatives 1–18 was synthesized and tested for their cytotoxic activity on a panel of 60 tumor cell lines. Additionally, molecular docking was carried out to study their binding pattern and binding affinity in the VEGFR-2 active site using sorafenib as a reference VEGFR-2 inhibitor. Based on the molecular docking results, compounds 5a, 5b, 6, 7, 14b, 18b, and 18c were selected to be evaluated for their VEGFR-2 inhibitory activity. Compound 18b exhibited a broad-spectrum antiproliferative activity on 47 cell lines, with GI % ranging from 31 to 82.5%. Moreover, compound 18b was the most potent VEGFR-2 inhibitor with an IC50 value of 0.07 μM, which is more potent than that of sorafenib (0.09 μM). A molecular docking study attributed the promising activity of this series to their hydrophobic interaction with the VEGFR-2 binding site hydrophobic side chains and their hydrogen bonding interaction with the key amino acids Glu885 and/or Asp1046.
Reaction of imidazole and indole with 4-ethoxyalkylidene-2-phenyl-2-oxazolin-5-one: Structure of the condensation products
Homami, Seyed-Saied,Mukerjee, Arya K.
, p. 359 - 361 (2007/10/02)
Imidazole (2) and indole (3a) react with 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (1b; R2=H) to give 4-(imidazol-1-ylmethylene)- and 4-skatylidene-2-phenyl-2-oxazolin-5-ones (1d and 1e), respectively.Their structure are discussed.
