133377-35-2

Basic information

• Product Name: methyl (Z)-3-phenyl-2-(trifluoromethyl)prop-2-enoate
• Synonyms: methyl (Z)-3-phenyl-2-(trifluoromethyl)prop-2-enoate
• CAS NO: 133377-35-2
• Molecular Weight: 230.186
• Mol File: 133377-35-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl (Z)-3-phenyl-2-(trifluoromethyl)prop-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (Z)-3-phenyl-2-(trifluoromethyl)prop-2-enoate(133377-35-2)
• EPA Substance Registry System: methyl (Z)-3-phenyl-2-(trifluoromethyl)prop-2-enoate(133377-35-2)

Safety Data

• Hazardous Substances Data: 133377-35-2(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 382-90-1 methyl α-trifluoromethylacrylate 
• 24127-62-6 methyl 2-bromo-3-phenylacrylate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 21788-36-3 (Z)-methyl 2-bromo-3-phenylacrylate 
• 371-76-6 bis(trifluoromethyl)mercury 
• 100-52-7 benzaldehyde 
• 173558-71-9 2-diazo-3,3,3-trifluoropropionic acid methyl ester 

Relevant articles and documents

Synthesis of α-Trifluoromethylacrylates by Ligand-Free Palladium-Catalyzed Mizoroki-Heck Reaction

Efficient ligand-free palladium catalyzed Mizoroki-Heck reaction allowed the formation of trisubstituted α-trifluoromethylacrylates. The reaction showed good chemical tolerance and furnished moderate to excellent yields of reaction. Silver salt additive proved to be essential for the reaction. The reaction has been then applied to the formation of 3-trifluoromethyl coumarins and analogues of therapeutic agents.

A synthetic three fluoro methyl acrylic acid derivative method

The invention relates to a novel method for synthesizing a derivative of trifluoromethyl acrylic acid. In the method, a target product with yield of more than 80% can be obtained with commercial trifluoropropionic acid (or esters thereof) and aldehyde as

Trifluoromethylation of alkenyl bromides and iodides (including 5-iodouracils) with (CF3)2Hg and Cu (" trifluoromethylcopper")

Bromo- and iodoalkenes undergo trifluoromethylation efficiently in DMA with "CF3Cu" generated from (CF3)2Hg and Cu. Variable stereochemical inversion is observed with substrates having a gem-carbonyl group. Substrates having gem-hydrogen, -alkyl, or -alkenyl groups give products with stereochemical retention.